RGD Reference Report - Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells. - Rat Genome Database

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Expression of Patched-1 and Smoothened in testicular meiotic and post-meiotic cells.

Authors: Morales, CR  Fox, A  El-Alfy, M  Ni, X  Argraves, WS 
Citation: Morales CR, etal., Microsc Res Tech. 2009 Nov;72(11):809-15.
RGD ID: 2324985
Pubmed: PMID:19484749   (View Abstract at PubMed)
DOI: DOI:10.1002/jemt.20733   (Journal Full-text)

Desert hedgehog (Dhh) signaling plays an essential role in the normal development of the testis and in the process of spermatogenesis. Little is known about the involvement in spermatogenesis of the prototypic member of the family, Ptc1, which acts to suppress hedgehog signaling through Smoothened (Smo). Here, we have examined the expression of Ptc1, Smo, and Dhh in mouse and rat seminiferous epithelium. Our findings demonstrate that Ptc1 and Smo are expressed by primary spermatocytes and by round and condensing spermatids whereas Dhh is expressed by Sertoli cells. The findings suggest that Sertoli cells coordinate Dhh-dependent spermatogenesis events via Ptc1 and Smo prior to the first meiotic division and in postmeiotic (haploid) cells, particularly during the first half of spermiogenesis.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
spermatogenesis  IEP 2324985 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Smo  (smoothened, frizzled class receptor)


Additional Information