RGD Reference Report - Early nuclear exclusion of the transcription factor max is associated with retinal ganglion cell death independent of caspase activity. - Rat Genome Database

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Early nuclear exclusion of the transcription factor max is associated with retinal ganglion cell death independent of caspase activity.

Authors: Petrs-Silva, H  De Freitas, FG  Linden, R  Chiarini, LB 
Citation: Petrs-Silva H, etal., J Cell Physiol. 2004 Feb;198(2):179-87.
RGD ID: 2316820
Pubmed: PMID:14603520   (View Abstract at PubMed)
DOI: DOI:10.1002/jcp.10404   (Journal Full-text)

We examined the behavior of the transcription factor Max during retrograde neuronal degeneration of retinal ganglion cells. Using immunohistochemistry, we found a progressive redistribution of full-length Max from the nucleus to the cytoplasm and dendrites of the ganglion cells following axon damage. Then, the axotomized cells lose all their content of Max, while undergoing nuclear pyknosis and apoptotic cell death. After treatment of retinal explants with either anisomycin or thapsigargin, the rate of nuclear exclusion of Max accompanied the rate of cell death as modulated by either drug. Treatment with a pan-caspase inhibitor abolished both TUNEL staining and immunoreactivity for activated caspase-3, but did not affect the subcellular redistribution of Max immunoreactivity after axotomy. The data show that nuclear exclusion of the transcription factor Max is an early event, which precedes and is independent of the activation of caspases, during apoptotic cell death in the central nervous system.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron apoptotic process  IEP 2316820 RGD 
response to axon injury  IEP 2316820 RGD 
retina development in camera-type eye  IEP 2316820 RGD 

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendrite  IDA 2316820 RGD 
nucleus  IDA 2316820 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Max  (MYC associated factor X)


Additional Information