RGD Reference Report - Involvement of an endogenous sialidase in skeletal muscle cell differentiation. - Rat Genome Database

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Involvement of an endogenous sialidase in skeletal muscle cell differentiation.

Authors: Sato, K  Miyagi, T 
Citation: Sato K and Miyagi T, Biochem Biophys Res Commun. 1996 Apr 25;221(3):826-30.
RGD ID: 2316563
Pubmed: PMID:8630046   (View Abstract at PubMed)
DOI: DOI:10.1006/bbrc.1996.0681   (Journal Full-text)

We have previously observed that the cytosolic sialidase gene is highly expressed in rat skeletal muscle and that it contains an enhancer/promoter region which is transcriptionally active in rat L6 myogenic cells. Here we present evidence for the involvement of cytosolic sialidase in myoblast differentiation. During L6 myoblast differentiation induced by serum depletion, cytosolic sialidase is increased in activity as well as in terms of mRNA level. Sialidase activity is essentially lacking in untreated myoblasts but appears concomitantly with myotube formation after induction of differentiation. The mRNA becomes able to be detected after 3 days at the time which myogenin mRNA reaches a maximum level. Myotube formation can, in fact, be blocked by the addition of an antisense oligodeoxyribonucleotide complementary to the first 8 codons of the cytosolic sialidase.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of myotube differentiation  IMP 2316563 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Neu2  (neuraminidase 2)


Additional Information