RGD Reference Report - Insulitis in human type 1 diabetes. - Rat Genome Database

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Insulitis in human type 1 diabetes.

Authors: Hanafusa, T  Imagawa, A 
Citation: Hanafusa T and Imagawa A, Ann N Y Acad Sci. 2008 Dec;1150:297-9.
RGD ID: 2315742
Pubmed: PMID:19120316   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1447.052   (Journal Full-text)

Pancreatic tissues were analyzed immunohistologically in patients with autoimmune and fulminant type 1 diabetes (T1D) and control subjects. Both beta and alpha cells were decreased in fulminant T1D, but only beta cells were significantly decreased in autoimmune T1D. Insulitis was seen in both subtypes of T1D, but it remained longer in autoimmune than in fulminant T1D. Lymphocytic infiltration to the exocrine pancreatic tissue was observed only in fulminant T1D, whereas immunologically abnormal findings, such as increased expression of MHC class I molecule and Fas antigen in islet cells and Fas-ligand expression in infiltrating lymphocytes, were detected only in autoimmune T1D. From these findings, together with clinical features, it could be concluded that in autoimmune T1D, beta cells are assumed to be destroyed through a long-standing autoimmune process, whereas in fulminant T1D, beta cells seem to be destroyed very rapidly, probably by a destructive process triggered by viral infection.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  IEP 2315742protein:increased expression:insulin-secreting cellsRGD 
type 1 diabetes mellitus  IEP 2315742protein:increased expression:lymphocyteRGD 
type 1 diabetes mellitus  ISOFAS (Homo sapiens)2315742; 2315742protein:increased expression:insulin-secreting cellsRGD 
type 1 diabetes mellitus  ISOFASLG (Homo sapiens)2315742; 2315742protein:increased expression:lymphocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)
Faslg  (Fas ligand)

Genes (Mus musculus)
Fas  (Fas cell surface death receptor)
Fasl  (Fas ligand)

Genes (Homo sapiens)
FAS  (Fas cell surface death receptor)
FASLG  (Fas ligand)


Additional Information