RGD Reference Report - DeltaNp63 protein expression in uterine cervical and endometrial cancers. - Rat Genome Database

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DeltaNp63 protein expression in uterine cervical and endometrial cancers.

Authors: Lin, Z  Liu, M  Li, Z  Kim, C  Lee, E  Kim, I 
Citation: Lin Z, etal., J Cancer Res Clin Oncol. 2006 Dec;132(12):811-6. Epub 2006 Jun 28.
RGD ID: 2315435
Pubmed: PMID:16804722   (View Abstract at PubMed)
DOI: DOI:10.1007/s00432-006-0130-8   (Journal Full-text)

PURPOSE: To investigate the significance of p63 expression in uterine cervical and endometrial cancers. MATERIALS AND METHODS: DeltaNp63 protein expression was studied in a variety of 127 cases of uterine cervical lesions (20 non-neoplastic cervices, 43 cervical intraepithelial neoplasia [CIN], 54 squamous cell carcinomas (SCCs), 40 adenocarcinomas, and 13 other histologic types) and 30 endometrioid type of endometrial adenocarcinomas by using immunohistochemistry. One SCC cell line (ME-180) and one adenocarcinoma cell line (HeLa) were also included. RESULTS: In uterine cervix, the expression of DeltaNp63 was increased with progression of CIN, and positive in all SCCs, transitional cell carcinomas, and adenoid basal carcinoma, but negative in all adenocarcinomas. Adenosquamous cell carcinoma and mixed neuroendocrine and squamous cell carcinoma were positive in squamous component, but not in adenocarcinoma and neuroendocrine carcinoma components. ME-180 cell line was positive, whereas HeLa cell line was negative. Endometrioid type of endometrial adenocarcinomas showed a positive staining in glandular (26.7%) and squamous component. CONCLUSIONS: Immunohistochemical staining for DeltaNp63 is a powerful marker for squamous differentiation and useful in exclusion of glandular and neuroendocrine differentiation in uterine cervical cancers, but not always in endometrial cancers.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
cervix uteri carcinoma in situ disease_progressionIEP 2315435 RGD 
cervix uteri carcinoma in situ disease_progressionISOTP63 (Homo sapiens)2315435; 2315435 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp63  (tumor protein p63)

Genes (Mus musculus)
Trp63  (transformation related protein 63)

Genes (Homo sapiens)
TP63  (tumor protein p63)


Additional Information