RGD Reference Report - The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats. - Rat Genome Database

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The CB1 receptor agonist, WIN 55,212-2, dose-dependently disrupts object recognition memory in adult rats.

Authors: Baek, J  Zheng, Y  Darlington, CL  Smith, PF 
Citation: Baek J, etal., Neurosci Lett. 2009 Oct 16;464(1):71-3. Epub 2009 Aug 8.
RGD ID: 2314648
Pubmed: PMID:19666083   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neulet.2009.08.008   (Journal Full-text)

Drugs that act as agonists at the cannabinoid CB(1) receptor have been reported to interfere with a diverse range of cognitive functions, including object recognition memory. However, to date, most of the studies conducted on this aspect of memory have suggested that these effects occur mainly in pubertal or pre-pubertal, rather than adult, rats. In this study we revisited this issue and evaluated the effects of a single s.c. injection of the CB(1) receptor agonist, WIN 55,212-2 ('WIN'), at 1, 3 or 5mg/kg, on object recognition memory. We found that WIN significantly reduced the total exploration time for objects at the 5mg/kg dose only (P<0.05). This was presumably due to its sedative effects at this dose. However, the discrimination index, which controlled for the general effects of WIN on object exploration, was significantly reduced only for the 1mg/kg WIN group (P<0.05), suggesting that only at this low dose did WIN specifically interfere with object discrimination. These results suggest that WIN can interfere with object recognition memory even in adult rats following a single injection of a low dose.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
memory  IDA 2314648 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cnr1  (cannabinoid receptor 1)


Additional Information