RGD Reference Report - Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis. - Rat Genome Database

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Urinary excretion of aquaporin-2 water channel in diabetic ketoacidosis.

Authors: Kusaka, I  Saito, T  Nakamura, T  Nagasaka, S  Ishibashi, S  Ishikawa, SE 
Citation: Kusaka I, etal., Nephron. 2002 May;91(1):167-9.
RGD ID: 2314345
Pubmed: PMID:12021537   (View Abstract at PubMed)
DOI: DOI:57622   (Journal Full-text)

We studied the changes in plasma arginine vasopressin (AVP) and urinary excretion of aquaporin-2 (UAQP-2) water channel in 3 patients with diabetic ketoacidosis. They had marked hyperglycemia of 27.9 +/- 2.8 mmol/l (mean +/- SEM), and elevated hemoglobin A1c of 8.8 +/- 1.4%. Circulatory blood volume was decreased by approximately 25%, which was determined by the changes in hematocrit. Plasma AVP levels were elevated to 10.3 +/- 3.0 pmol/l and UAQP-2, 578 +/- 200 fmol/mg creatinine (normal, 153 +/- 28) at the hospitalization. When hyperglycemia was improved by the intravenous infusion of a small dose of insulin plus fluid administration, both plasma AVP and UAQP-2 promptly decreased to 1.2 +/- 0.2 pmol/l and 252 +/- 29 fmol/mg creatinine on day 7, respectively. These alterations were concomitant with the recovery of circulatory blood volume. In the present study, UAQP-2, in addition to plasma AVP, indicates circulatory blood volume depletion, and the changes in UAQP-2 estimates the AVP-dependent recovery of circulatory blood volume during the therapeutic period in the patients with diabetic ketoacidosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetic ketoacidosis  IEP 2314345 RGD 
diabetic ketoacidosis  ISOAQP2 (Homo sapiens)2314345; 2314345 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp2  (aquaporin 2)

Genes (Mus musculus)
Aqp2  (aquaporin 2)

Genes (Homo sapiens)
AQP2  (aquaporin 2)


Additional Information