RGD Reference Report - Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene. - Rat Genome Database

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Novel treatment for lithium-induced nephrogenic diabetes insipidus rat model using the Sendai-virus vector carrying aquaporin 2 gene.

Authors: Suga, H  Nagasaki, H  Kondo, TA  Okajima, Y  Suzuki, C  Ozaki, N  Arima, H  Yamamoto, T 
Citation: Suga H, etal., Endocrinology. 2008 Nov;149(11):5803-10. Epub 2008 Jul 24.
RGD ID: 2314292
Pubmed: PMID:18653713   (View Abstract at PubMed)

Congenital nephrogenic diabetes insipidus (NDI) is a chronic disorder involving polyuria and polydipsia that results from unresponsiveness of the renal collecting ducts to the antidiuretic hormone vasopressin. Either of the genetic defects in vasopressin V2 receptor or the water channel aquaporin 2 (AQP2) cause the disease, which interfere the water reabsorption at the epithelium of the collecting duct. An unconscious state including a perioperative situation can be life threatening because of the difficulty to regulate their water balance. The Sendai virus (SeV) vector system deleting fusion protein (F) gene (SeV/DeltaF) is considered most suitable because of the short replication cycle and nontransmissible character. An animal model for NDI with reduced AQP2 by lithium chloride was used to develop the therapy. When the SeV/DeltaF vector carrying a human AQP2 gene (AQP2-SeV/DeltaF) was administered retrogradely via ureter to renal pelvis, AQP2 was expressed in the renal collecting duct to reduce urine output and water intake by up to 40%. In combination with the retorograde administration to pelvis, this system could be the cornerstone for the applicable therapies on not only NDI patients but also other diseases associate with the medullary collecting duct.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
nephrogenic diabetes insipidus  IMP 2314292 RGD 
nephrogenic diabetes insipidus  ISOAQP2 (Homo sapiens)2314292; 2314292 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aqp2  (aquaporin 2)

Genes (Mus musculus)
Aqp2  (aquaporin 2)

Genes (Homo sapiens)
AQP2  (aquaporin 2)


Additional Information