RGD Reference Report - Plasma fetuin-A levels and the risk of type 2 diabetes. - Rat Genome Database

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Plasma fetuin-A levels and the risk of type 2 diabetes.

Authors: Stefan, N  Fritsche, A  Weikert, C  Boeing, H  Joost, HG  Haring, HU  Schulze, MB 
Citation: Stefan N, etal., Diabetes. 2008 Oct;57(10):2762-7. Epub 2008 Jul 15.
RGD ID: 2313811
Pubmed: PMID:18633113   (View Abstract at PubMed)
PMCID: PMC2551687   (View Article at PubMed Central)
DOI: DOI:10.2337/db08-0538   (Journal Full-text)

OBJECTIVE: The liver-secreted protein fetuin-A induces insulin resistance in animals, and circulating fetuin-A is elevated in insulin resistance and fatty liver in humans. We investigated whether plasma fetuin-A levels predict the incidence of type 2 diabetes in a large prospective, population-based study. RESEARCH DESIGN AND METHODS: A case-cohort study within the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam study comprising 27,548 subjects was designed. We randomly selected a subcohort of 2,500 individuals of whom 2,164 were diabetes free at baseline and had anamnestic, anthropometrical, and metabolic data for analysis. Of the 849 incident diabetic case subjects identified in the full cohort during 7 years of follow-up, 703 remained for analyses after similar exclusions. RESULTS: Plasma fetuin-A levels were positively associated with diabetes risk after adjustment for age (relative risk [RR] for extreme quintiles 1.75 [95% CI 1.32-2.31]; RR for 10 mug/ml 1.04 [1.03-1.06]). The association remained significant after adjustment for sex, BMI, waist circumference, and lifestyle risk factors (RR for 10 mug/ml 1.03 [1.01-1.06]). Adjustment for glucose, triglycerides, HDL cholesterol, A1C, gamma-glutamyltransferase, or high-sensitivity C-reactive protein or mutual adjustment for these biomarkers did not appreciably change this result (RR for 10 mug/ml full adjusted model 1.05 [1.02-1.07]). Furthermore, fetuin-A was associated with increased diabetes risk particularly in individuals with elevated plasma glucose. CONCLUSIONS: Our data suggest that fetuin-A is an independent risk factor of type 2 diabetes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 2 diabetes mellitus  IEP 2313811 RGD 
type 2 diabetes mellitus  ISOAHSG (Homo sapiens)2313811; 2313811 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ahsg  (alpha-2-HS-glycoprotein)

Genes (Mus musculus)
Ahsg  (alpha-2-HS-glycoprotein)

Genes (Homo sapiens)
AHSG  (alpha 2-HS glycoprotein)


Additional Information