RGD Reference Report - Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats. - Rat Genome Database

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Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats.

Authors: Kuntz, E  Pinget, M  Damge, P 
Citation: Kuntz E, etal., JOP. 2004 Nov 10;5(6):464-75.
RGD ID: 2313638
Pubmed: PMID:15536283   (View Abstract at PubMed)

CONTEXT: Diabetes is associated with the reduction of beta cell mass and activity. Cholecystokinin (CCK) is known to induce growth of the exocrine pancreas and to stimulate insulin secretion. OBJECTIVE: We investigated the possible role of CCK-octapeptide (CCK-8) in generating islet cell proliferation in type 1 and type 2 diabetic rats. METHODS: Streptozotocin-induced type 1 diabetic rats, streptozotocin/nicotinamide-induced type 2 diabetic rats and non-diabetic rats were subjected to CCK-8 (1, 2 and 4 microg/kg) or saline injections (for the control group), three times daily for 8 successive days. MAIN OUTCOME MEASURES: The islets of Langerhans were analyzed morphometrically; the beta-cell function was evaluated by an oral glucose tolerance test, and plasma basal glucose and insulin concentrations. RESULTS: In type 1 diabetic rats, CCK-8 induced an increase in beta cell surface associated with a marked increase in the mitotic index; this effect appeared at a concentration of 1 microg/kg CCK-8 and was the highest at a concentration of 4 microg/kg CCK-8. In addition, pancreatic- and plasma-insulin concentrations increased while fasting blood glucose concentrations were reduced when compared to saline-treated rats but the glycemic response to an oral glucose challenge did not significantly improve. In type 2 diabetic rats and in non-diabetic rats, CCK-8 treatment did not significantly affect either the structure or the functional state of beta-cells. CONCLUSIONS: CCK-8 could improve blood glucose concentrations in type 1 diabetic rats correlated with an increase in beta cell mass probably potentiated by the chronic hyperglycemic state.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOCck (Rattus norvegicus)2313638; 2313638 RGD 
Experimental Diabetes Mellitus  IDA 2313638 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of cell population proliferation  IDA 2313638 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cck  (cholecystokinin)

Genes (Mus musculus)
Cck  (cholecystokinin)

Genes (Homo sapiens)
CCK  (cholecystokinin)


Additional Information