RGD Reference Report - mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging. - Rat Genome Database

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mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging.

Authors: Frank, MG  Barrientos, RM  Biedenkapp, JC  Rudy, JW  Watkins, LR  Maier, SF 
Citation: Frank MG, etal., Neurobiol Aging. 2006 May;27(5):717-22.
RGD ID: 2313439
Pubmed: PMID:15890435   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neurobiolaging.2005.03.013   (Journal Full-text)

In normal brain aging, CNS resident macrophages exhibit increased expression of major histocompatibility complex (MHC) II expression. However, the transcriptional basis for this observation has not been clarified nor have age-related alterations in pivotal pro-inflammatory genes been characterized. Age-related mRNA alterations in MHC II, MHC II accessory molecules and several pro-inflammatory mediators were measured in older (24 months) and younger (3 months) male F344xBN F1 rats. Real time RT-PCR was utilized to measure steady state mRNA levels in hippocampus. Older as compared to younger animals exhibited increased mRNA levels of MHC II, CD86, CIITA and IFN-gamma. Furthermore, IL-10 and CD200 mRNA, molecules that down-regulate macrophage activation, was decreased in older animals. The present results indicate that normal brain aging is characterized by a shift towards a pro-inflammatory microenvironment in the CNS.

Objects referenced in this article
Gene Cd86 CD86 molecule Rattus norvegicus
Gene Ciita class II, major histocompatibility complex, transactivator Rattus norvegicus

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