RGD Reference Report - Adaptation to low-protein diet increases inhibition of gastric emptying by CCK. - Rat Genome Database

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Adaptation to low-protein diet increases inhibition of gastric emptying by CCK.

Authors: Leray, V  Segain, JP  Cherbut, C  Galmiche, JP 
Citation: Leray V, etal., Peptides. 2003 Dec;24(12):1929-34.
RGD ID: 2313376
Pubmed: PMID:15127944   (View Abstract at PubMed)

Chronic nutritional disorders such as protein malnutrition are associated with delayed gastric emptying and increased postprandial cholecystokinin (CCK) levels. This study investigated the mechanisms involved in gastric emptying adaptation to low-protein diet. Two groups of 12 rats were adapted to a low-protein (LPD) or standard diet (SD) for 3 weeks. As compared to rats fed a SD, in rats adapted to a LPD gastric emptying was delayed, whereas postprandial CCK levels were increased. LPD enhanced antral muscle contractile response to CCK and cerulein without altering response to acetylcholine. This increased contractility was associated with up-regulation of CCK-A receptor mRNA levels in antral muscle. Our data suggest that modulation of gastric emptying after adaptation to a low-protein diet involves up-regulation of both CCK-A receptors and CCK-induced contraction of antral smooth muscle.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to nutrient  IEP 2313376 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cckar  (cholecystokinin A receptor)


Additional Information