RGD Reference Report - Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus. - Rat Genome Database

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Endothelin-1 levels and albuminuria in patients with type 2 diabetes mellitus.

Authors: Zanatta, CM  Gerchman, F  Burttet, L  Nabinger, G  Jacques-Silva, MC  Canani, LH  Gross, JL 
Citation: Zanatta CM, etal., Diabetes Res Clin Pract. 2008 May;80(2):299-304. Epub 2008 Mar 17.
RGD ID: 2313284
Pubmed: PMID:18346810   (View Abstract at PubMed)
DOI: DOI:10.1016/j.diabres.2007.12.024   (Journal Full-text)

AIM: To evaluate the relationship of plasma endothelin-1 (ET-1) levels, a marker of endothelial dysfunction, and urinary albumin excretion in patients with type 2 diabetes mellitus (DM). METHODS: Cross-sectional study was conducted in 279 patients (132 males, mean age: 58.7+/-11.0 years, mean DM duration: 11.3+/-8.1 years). Urinary albumin excretion, ET-1, and insulin were measured. Insulin sensitivity was estimated by homeostasis model assessment (HOMA-ir) index. RESULTS: ET-1 was associated with urinary albumin excretion after controlling for age, gender, body mass index, blood pressure, HbA1c test, and total cholesterol (R=0.436; adjusted R(2)=0.190, P<0.01). Furthermore, there was a progressive increase in plasma ET-1 levels from patients with normoalbuminuria (n=187, 0.92+/-0.50pg/ml), microalbuminuria (n=68, 1.13+/-0.52pg/ml) to macroalbuminuria (n=24, 1.93+/-1.10pg/ml, P<0.01). CONCLUSION: There is an independent association of plasma ET-1 levels with urinary albumin excretion. In addition, plasma ET-1 levels started to increase in the normal values of urinary albumin excretion suggesting that in patients with type 2 DM endothelial dysfunction is already present, in urinary albumin excretion values considered normal.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Diabetic Nephropathies  IEP 2313284associated with Diabetes Mellitus more ...RGD 
Diabetic Nephropathies  ISOEDN1 (Homo sapiens)2313284; 2313284associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Edn1  (endothelin 1)

Genes (Mus musculus)
Edn1  (endothelin 1)

Genes (Homo sapiens)
EDN1  (endothelin 1)


Additional Information