RGD Reference Report - G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. - Rat Genome Database

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G-protein beta3 subunit (GNB3) gene polymorphisms and cardiovascular disease: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.

Authors: Renner, W  Hoffmann, MM  Grunbacher, G  Winkelmann, BR  Boehm, BO  Marz, W 
Citation: Renner W, etal., Atherosclerosis. 2007 May;192(1):108-12. Epub 2006 Aug 14.
RGD ID: 2313206
Pubmed: PMID:16908025   (View Abstract at PubMed)
DOI: DOI:10.1016/j.atherosclerosis.2006.07.001   (Journal Full-text)

A common 825C>T polymorphism in exon 10 of the gene for the beta-3 subunit of heterotrimeric G-proteins, GNB3, has been associated in some studies with traits of the metabolic syndrome as well as coronary artery disease (CAD), but these associations were refuted by other studies. To investigate the role of GNB3 gene variations in CAD and myocardial infarction (MI), we determined five GNB3 polymorphisms (-1429G>A, IVS5 +41G>A, 657T>A, 814G>A and 825C>T) in the Ludwigshafen Risk and Cardiovascular Health (LURIC) cohort, including 2575 patients with angiographically documented CAD and 731 individuals in whom CAD had been ruled out by angiography. None of the GNB3 polymorphisms was associated with CAD, MI, diabetes, hypertension, blood pressure, body weight or body mass index. We conclude that a major contribution of GNB3 gene variants to CAD or MI risk is unlikely.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
diabetes mellitus no_associationIAGP 2313206DNA:polymorphism: :multiple (human)RGD 
diabetes mellitus no_associationISOGNB3 (Homo sapiens)2313206; 2313206DNA:polymorphism: :multiple (human)RGD 
hypertension no_associationIAGP 2313206DNA:polymorphism: :multiple (human)RGD 
hypertension no_associationISOGNB3 (Homo sapiens)2313206; 2313206DNA:polymorphism: :multiple (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gnb3  (G protein subunit beta 3)

Genes (Mus musculus)
Gnb3  (guanine nucleotide binding protein (G protein), beta 3)

Genes (Homo sapiens)
GNB3  (G protein subunit beta 3)


Additional Information