RGD Reference Report - Association of the C825T polymorphism of the G-protein beta3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese. - Rat Genome Database

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Association of the C825T polymorphism of the G-protein beta3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese.

Authors: Hayakawa, T  Takamura, T  Abe, T  Kaneko, S 
Citation: Hayakawa T, etal., Metabolism. 2007 Jan;56(1):44-8.
RGD ID: 2313205
Pubmed: PMID:17161225   (View Abstract at PubMed)
DOI: DOI:10.1016/j.metabol.2006.08.020   (Journal Full-text)

A C825T polymorphism of the gene encoding the G-protein beta3 subunit (GNB3) is associated with increased intracellular signal transduction. We know that this C825T polymorphism may influence hypertension and obesity. In whites, the C825T polymorphism has been reported to induce hypertension, obesity, and diabetic nephropathy. Thus, we investigated how genetic variation in the GNB3 gene is associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, and diabetic therapies in 427 Japanese subjects with type 2 diabetes mellitus and in 368 Japanese subjects who underwent general health examinations. The frequency of the GNB3 gene polymorphism was 0.48 and 0.47 in subjects with diabetes and in those who had general health examinations, respectively. The amount of hyperlipidemia of the CT allele was significantly lower than the amount in the CC allele in the Japanese subjects with diabetes. Our results suggest that the C825T polymorphism influences lipid metabolism and is not associated with hypertension, obesity, insulin resistance, diabetes, diabetic complications, or diabetic therapies.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
familial hyperlipidemia susceptibilityIAGP 2313205associated with Diabetes Mellitus more ...RGD 
familial hyperlipidemia susceptibilityISOGNB3 (Homo sapiens)2313205; 2313205associated with Diabetes Mellitus more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gnb3  (G protein subunit beta 3)

Genes (Mus musculus)
Gnb3  (guanine nucleotide binding protein (G protein), beta 3)

Genes (Homo sapiens)
GNB3  (G protein subunit beta 3)


Additional Information