RGD Reference Report - Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility. - Rat Genome Database

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Association of the polymorphism for Toll-like receptor 2 with type 1 diabetes susceptibility.

Authors: Park, Y  Park, S  Yoo, E  Kim, D  Shin, H 
Citation: Park Y, etal., Ann N Y Acad Sci. 2004 Dec;1037:170-4.
RGD ID: 2312686
Pubmed: PMID:15699513   (View Abstract at PubMed)
DOI: DOI:10.1196/annals.1337.028   (Journal Full-text)

Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease in which pancreatic beta cells are selectively destroyed. Although autoimmune diseases are driven by inappropriate adaptive immunity, innate immunity may play a role in the development of T1DM. We investigated the association of the genes for toll-like receptor 2 (TLR2), one of the key surface receptors on innate effectors, with T1DM in Korean patients. Genetic association analyses revealed that the genotype composed of the rare allele (CC) of TLR2 1350 showed weak and protective association with T1DM (OR = 1.7, 95% CI: 1.1-2.7; P < .05) irrespective of the duration of disease, age, and autoantibody status. One of the TLR2 SNP haplotypes, TLR2-Ht4, was strongly associated with T1DM in that those subjects having more than one copy of Ht4 showed strong protection from developing T1DM (OR = 90.5; 95% CI: 13.8-235.7; P < 10(-5)). The TLR2 polymorphisms are associated with T1DM, and distribution differences between T1DM versus controls were not influenced by the HLA genes. There is a close relationship between innate and adaptive immunity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  IAGP 2312686DNA:SNP: :1350T>C (human)RGD 
type 1 diabetes mellitus  ISOTLR2 (Homo sapiens)2312686; 2312686DNA:SNP: :1350T>C (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tlr2  (toll-like receptor 2)

Genes (Mus musculus)
Tlr2  (toll-like receptor 2)

Genes (Homo sapiens)
TLR2  (toll like receptor 2)


Additional Information