RGD Reference Report - Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi. - Rat Genome Database

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Role of Syndecan-4 in the cellular invasion of Orientia tsutsugamushi.

Authors: Kim, HR  Choi, MS  Kim, IS 
Citation: Kim HR, etal., Microb Pathog. 2004 Apr;36(4):219-25.
RGD ID: 2312325
Pubmed: PMID:15001228   (View Abstract at PubMed)
DOI: DOI:10.1016/j.micpath.2003.12.005   (Journal Full-text)

Cell surface heparan sulfate proteoglycans (HSPGs) play a critical role in the cellular invasion of intracellular bacteria and are presumed to have a role in the infection of host cells by Orientia tsutsugamushi. Previously, we showed that O. tsutsugamushi infection decreased markedly after treating host cells with heparinase, which suggests that HSPGs play an important role in oriential infection. We tested oriential infection in REF-Syn4 cells over-expressing syndecan-4, and in REF-Syn4AS cells in which the expression of syndecan-4 was down regulated by transfecting with anti-sense syndecan-4 cDNA. Oriential infection was found to be dependent on the expression level of syndecan-4 on the cell surface. Furthermore, the infectivity of O. tsutsugamushi was specifically reduced by treating O. tsutsugamushi with the purified recombinant core protein of syndecan-4 (Syn4E). These results suggest that the core protein of syndecan-4 and the heparin/heparan sulfate chain of syndecan play an important role in oriential infection by O. tsutsugamushi.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bacterial infectious disease  ISOSdc4 (Rattus norvegicus)2312325; 2312325 RGD 
bacterial infectious disease  IMP 2312325 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Sdc4  (syndecan 4)

Genes (Mus musculus)
Sdc4  (syndecan 4)

Genes (Homo sapiens)
SDC4  (syndecan 4)

Objects referenced in this article
Gene Sdc1 syndecan 1 Rattus norvegicus

Additional Information