RGD Reference Report - Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats--role of vitamin K-dependent clotting factors and prevention by low-intensity oral anticoagulation.

General

Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats--role of vitamin K-dependent clotting factors and prevention by low-intensity oral anticoagulation.
Authors:	De Curtis, A D'Adamo, MC Amore, C Polishchuck, R Castelnuovo, AD Donati, MB Iacoviello, L
Citation:	De Curtis A, etal., Thromb Haemost. 2001 Dec;86(6):1440-8.
RGD ID:	2312300
Pubmed:	PMID:11776312 (View Abstract at PubMed)
To investigate the relationship among lipids, coagulation and thrombosis in the absence of atherosclerosis, spontaneous or dietary-induced hyperlipidemic (FHL) rats were studied. FHL showed higher levels of coagulation factors VII, IX, X, VIII and XII and a shortening of the occlusion time (OT) of an artificial arterial prosthesis as compared with normolipidemic (FNL) animals. Damage of abdominal aorta of FHL was followed by increased fibrin deposition in the vascular intima as compared to FNL. After 5 months of cholesterol-rich diet FNL showed increased cholesterol, triglycerides and factor II, VII, IX, X, XII levels. A significant shortening of the OT and increased fibrin deposition was also observed. Two-month diet withdrawal restored the initial condition. Warfarin treatment, at a dose decreasing vitamin K-dependent factor to levels found in FNL, prolonged the OT and reduced fibrin deposition, without modifying F XII or changing lipid profile. An increase in the activated form of F VII was observed. In contrast, no difference was found in F VII clearance. High lipid levels favour the process of thrombus formation by increasing the activation of vitamin K-dependent coagulation factors. Low-dose warfarin treatment reverts the prothrombotic effect of hyperlipidemia.

RGD Manual Disease Annotations Click to see Annotation Detail View

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
familial hyperlipidemia		IEP		2312300	protein:increased expression:plasma (rat)	RGD
familial hyperlipidemia		ISO	F7 (Rattus norvegicus)	2312300; 2312300	protein:increased expression:plasma (rat)	RGD

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Biological Process

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
response to organic cyclic compound		IEP		2312300	warfarin	RGD

Objects Annotated

Genes (Rattus norvegicus)

F7 (coagulation factor VII)

Genes (Mus musculus)

F7 (coagulation factor VII)

Genes (Homo sapiens)

F7 (coagulation factor VII)

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Experimental arterial thrombosis in genetically or diet induced hyperlipidemia in rats--role of vitamin K-dependent clotting factors and prevention by low-intensity oral anticoagulation.