RGD Reference Report - mRNA expression of growth factors in glomeruli from diabetic rats. - Rat Genome Database

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mRNA expression of growth factors in glomeruli from diabetic rats.

Authors: Nakamura, T  Fukui, M  Ebihara, I  Osada, S  Nagaoka, I  Tomino, Y  Koide, H 
Citation: Nakamura T, etal., Diabetes. 1993 Mar;42(3):450-6.
RGD ID: 2311650
Pubmed: PMID:8094359   (View Abstract at PubMed)

Evaluations of glomerular mRNA levels encoding for PCNA, TNF-alpha, PDGF-A and -B chains, TGF-beta, IGF-I, bFGF, and EGF were made at 4, 12, and 24 wk after injection of STZ in Sprague-Dawley rats. The mRNA levels for PCNA, TNF-alpha, PDGF-B chain, TGF-beta, and bFGF increased with age in STZ-induced diabetic rats. At 24 wk after STZ injection, mRNA levels for PCNA, TNF-alpha, PDGF-B chain, TGF-beta, and bFGF were increased 3.8-fold, (P < 0.01), 4.2-fold (P < 0.01), 4.0-fold (P < 0.01), 5.2-fold (P < 0.001), and 3.6-fold (P < 0.01), respectively, in the glomeruli of diabetic rats when compared with control rats. In contrast, mRNA levels for IGF-I, PDGF-A chain, and EGF were not altered in glomeruli from diabetic and control rats throughout the experimental period. Insulin treatment partially ameliorated the increase in mRNA levels for PCNA, TNF-alpha, PDGF-B chain, TGF-beta, and bFGF in the glomeruli of diabetic rats. These data indicate that alterations in growth factor mRNA levels in glomeruli may be a manifestation of diabetic nephropathy, and that hyperglycemia or insulin deficiency may play a role in abnormal growth factor gene regulation.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOPdgfb (Rattus norvegicus)2311650; 2311650mRNA:increased expression:glomerulusRGD 
Experimental Diabetes Mellitus  IEP 2311650mRNA:increased expression:glomerulusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdgfb  (platelet derived growth factor subunit B)

Genes (Mus musculus)
Pdgfb  (platelet derived growth factor, B polypeptide)

Genes (Homo sapiens)
PDGFB  (platelet derived growth factor subunit B)


Additional Information