RGD Reference Report - Brain D1 dopamine receptor in alloxan-induced diabetes. - Rat Genome Database

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Brain D1 dopamine receptor in alloxan-induced diabetes.

Authors: Salkovic, M  Lackovic, Z 
Citation: Salkovic M and Lackovic Z, Diabetes. 1992 Sep;41(9):1119-21.
RGD ID: 2311600
Pubmed: PMID:1386820   (View Abstract at PubMed)

Specific binding of [3H]SCH 23390 to dopamine D1 receptors in the striatum and olfactory tubercle in 14-day alloxan-induced diabetic rats was investigated. The Scatchard analysis revealed decreased D1 receptor density in the striatum (Bmax values were 548 +/- 23 fmol/mg protein for the control and 466 +/- 33 fmol/mg for the diabetic rats). No change was observed in the olfactory tubercle (Bmax; 299 +/- 27 fmol/mg for the control and 317 +/- 32 fmol/mg for the diabetic rats). Thus, specific binding of [3H]SCH 23390 to striatal and olfactory tubercle membranes showed region-specific changes of brain dopamine D1 receptors in alloxan diabetic rats.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISODrd1 (Rattus norvegicus)2311600; 2311600protein:decreased activity:striatum (rat)RGD 
Experimental Diabetes Mellitus  IEP 2311600protein:decreased activity:striatum (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Drd1  (dopamine receptor D1)

Genes (Mus musculus)
Drd1  (dopamine receptor D1)

Genes (Homo sapiens)
DRD1  (dopamine receptor D1)


Additional Information