RGD Reference Report - Aberrant endometrial features of pregnancy in diabetic NOD mice. - Rat Genome Database

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Aberrant endometrial features of pregnancy in diabetic NOD mice.

Authors: Burke, SD  Dong, H  Hazan, AD  Croy, BA 
Citation: Burke SD, etal., Diabetes. 2007 Dec;56(12):2919-26. Epub 2007 Sep 7.
RGD ID: 2311544
Pubmed: PMID:17827401   (View Abstract at PubMed)
PMCID: PMC2949414   (View Article at PubMed Central)
DOI: DOI:10.2337/db07-0773   (Journal Full-text)

OBJECTIVE: Pregnant diabetic women are at a 4-12 times higher risk for preeclampsia, an urgent acute-onset complication of mid- to late gestation, than normal pregnant women. Hallmarks of preeclampsia are hypertension, proteinuria, and incomplete modification of endometrial spiral arteries. Transient proangiogenic lymphocytes called uterine natural killer (uNK) cells are implicated in human and rodent spiral artery modification. We studied mid- to late gestations in spontaneously type 1 diabetic NOD mice to investigate whether diabetes alters uNK cell homing and/or function. RESEARCH DESIGN AND METHODS: Normoglycemic, pre-diabetic, and diabetic NOD mice and controls were mated. Lymphocytes and endometrial endothelium and decidua were studied histologically and in functional assays. RESULTS: Conception accelerated progression to overt diabetes in NOD females who had limited spiral artery development, heavier placentas, and lighter fetuses displaying numerous birth defects compared with controls. UNK cell numbers were reduced in the decidua basalis of diabetic females, whereas interferon-gamma production was elevated. In diabetic NOD mice, decidual expression of the mucosal vascular addressin cell adhesion molecule (MAdCAM)-1 was aberrant in position, whereas vascular cell adhesion molecule (VCAM)-1 expression was reduced. Assays of lymphocyte adhesion to tissue sections under shear forces indicated that diabetes compromises the potential homing functions of both endometrial endothelium and peripheral NK cells. CONCLUSIONS: In diabetes, gestational endometrium has immune and vascular defects that likely contribute to murine fetal loss and birth defects. Analogous problems and preeclampsia in diabetic women may involve similar mechanisms.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus  ISOMadcam1 (Mus musculus)2311544; 2311544 RGD 
type 1 diabetes mellitus  IEP 2311544 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Madcam1  (mucosal vascular addressin cell adhesion molecule 1)

Genes (Mus musculus)
Madcam1  (mucosal vascular addressin cell adhesion molecule 1)

Genes (Homo sapiens)
MADCAM1  (mucosal vascular addressin cell adhesion molecule 1)


Additional Information