RGD Reference Report - HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus. - Rat Genome Database

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HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus.

Authors: Roep, BO  Duinkerken, G  Schreuder, GM  Kolb, H  De Vries, RR  Martin, S 
Citation: Roep BO, etal., Eur J Immunol. 1996 Jun;26(6):1285-9.
RGD ID: 2311488
Pubmed: PMID:8647206   (View Abstract at PubMed)
DOI: DOI:10.1002/eji.1830260616   (Journal Full-text)

Insulin-dependent diabetes mellitus (IDDM) is a T cell-dependent immune-mediated disease. Recently, a novel islet cell antigen (ICA69) recognized by autoantibodies was described. We tested T cell responsiveness to ICA69 in peripheral blood of patients with recent onset IDDM (n = 46), patients with long-standing IDDM (n = 44), non-diabetic age-matched, islet cell autoantibody- and glutamic acid decarboxylase (GAD)65 antibody-negative first-degree relatives of IDDM patients (n = 15) and rheumatoid arthritis patients (n = 22). T cell responsiveness was significantly higher in recent onset IDDM patients, compared to IDDM patients post-disease onset, non-diabetic first degree relatives and rheumatoid arthritis patients (p < 0.001). In responding IDDM patients a significant inverse correlation between T cell and autoantibody responsiveness to ICA69 was observed (p < 0.0005). Immunogenetic evaluation revealed an association of HLA-DR3 with T cell responsiveness to ICA69 (p < 0.02) and absence of ICA69-reactive autoantibodies (p < 0.04). The increased T cell reactivity to ICA69 in the absence of antibody reactivity at onset of IDMM is associated with an HLA class II immune response gene, and therefore suggestive of a genetically controlled selective activation of T helper subsets to a specific autoantigen in humans.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
type 1 diabetes mellitus onsetIDA 2311488 RGD 
type 1 diabetes mellitus onsetISOICA1 (Homo sapiens)2311488; 2311488 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ica1  (islet cell autoantigen 1)

Genes (Mus musculus)
Ica1  (islet cell autoantigen 1)

Genes (Homo sapiens)
ICA1  (islet cell autoantigen 1)


Additional Information