RGD Reference Report - Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity. - Rat Genome Database

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Down-regulation of striatin, a neuronal calmodulin-binding protein, impairs rat locomotor activity.

Authors: Bartoli, M  Ternaux, JP  Forni, C  Portalier, P  Salin, P  Amalric, M  Monneron, A 
Citation: Bartoli M, etal., J Neurobiol. 1999 Aug;40(2):234-43.
RGD ID: 2311297
Pubmed: PMID:10413453   (View Abstract at PubMed)

Striatin, an intraneuronal, calmodulin-binding protein addressed to dendrites and spines, is expressed in the motor system, particularly the striatum and motoneurons. Striatin contains a high number of domains mediating protein-protein interactions, suggesting a role within a dendritic Ca(2+)-signaling pathway. Here, we explored the hypothesis of a direct role of striatin in the motor control of behaving rats, by using an antisense strategy based on oligodeoxynucleotides (ODN). Rats were treated by intracerebroventricular infusion of a striatin antisense ODN (A-ODN) or mismatch ODN (M-ODN) delivered by osmotic pumps over 6 days. A significant decrease in the nocturnal locomotor activity of A-ODN-treated rats was observed after 5 days of treatment. Hypomotricity was correlated with a 60% decrease in striatin content of the striata of A-ODN-treated rats sacrificed on day 6. Striatin thus plays a role in the control of motor function. To approach the cellular mechanisms in which striatin is involved, striatin down-regulation was studied in a comparatively simpler model: purified rat spinal motoneurons which retain their polarity in culture. Treatment of cells by the striatin A-ODN resulted in the impairement of the growth of dendrites but not axon. The decrease in dendritic growth paralleled the loss of striatin. This model allows analysis of the molecular basis of striatin function in the dynamic changes occurring in growing dendrites, and offers clues to unravel its function within spines.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
dendrite development  IMP 2311297 RGD 
locomotory behavior  IMP 2311297 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Strn  (striatin)


Additional Information