RGD Reference Report - Lipoprotein lipase in experimental diabetic rats: beneficial effect of vanadate treatment. - Rat Genome Database

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Lipoprotein lipase in experimental diabetic rats: beneficial effect of vanadate treatment.

Authors: Levy, E  Bendayan, M 
Citation: Levy E and Bendayan M, Diabete Metab. 1991 Jan-Feb;17(1):44-8.
RGD ID: 2308849
Pubmed: PMID:1868959   (View Abstract at PubMed)

Elevated values of circulating triglycerides were observed in streptozotocin-hyperglycemic rat while cholesterol concentrations did not differ from controls. Daily oral administration of sodium metavanadate to these diabetic animals normalized blood glucose values without raising the reduced levels of insulin. Concomitant with the normalization of the glycemia, the elevated triglyceride values found in diabetic rats were also corrected. Lipoprotein lipase activity in adipose and cardiac tissues was significantly decreased in the streptozotocin-diabetic animals. Similarly, the hepatic lipase activity was also depressed. After vanadate treatment, lipoprotein lipase as well as hepatic lipase activities were corrected towards normal values. Thus, vanadate treatment of streptozotocin-diabetic animals induces normalization of blood glucose and triglycerides levels, while maintaining low amounts of circulating insulin. It also restores the depressed activities of adipose and cardiac lipoprotein lipase and hepatic lipase.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Diabetes Mellitus  ISOLipc (Rattus norvegicus)2308849; 2308849protein:decreased activity:liver (rat)RGD 
Experimental Diabetes Mellitus  IEP 2308849protein:decreased activity:liver (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Lipc  (lipase C, hepatic type)

Genes (Mus musculus)
Lipc  (lipase, hepatic)

Genes (Homo sapiens)
LIPC  (lipase C, hepatic type)


Additional Information