RGD Reference Report - Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action. - Rat Genome Database

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Annexin 1 peptides protect against experimental myocardial ischemia-reperfusion: analysis of their mechanism of action.

Authors: La, M  D'Amico, M  Bandiera, S  Di Filippo, C  Oliani, SM  Gavins, FN  Flower, RJ  Perretti, M 
Citation: La M, etal., FASEB J. 2001 Oct;15(12):2247-56.
RGD ID: 2306910
Pubmed: PMID:11641252   (View Abstract at PubMed)
DOI: DOI:10.1096/fj.01-0196com   (Journal Full-text)

Myocardial reperfusion injury is associated with the infiltration of blood-borne polymorphonuclear leukocytes. We have previous described the protection afforded by annexin 1 (ANXA1) in an experimental model of rat myocardial ischemia-reperfusion (IR) injury. We examined the 1) amino acid region of ANXA1 that retained the protective effect in a model of rat heart IR; 2) changes in endogenous ANXA1 in relation to the IR induced damage and after pharmacological modulation; and 3) potential involvement of the formyl peptide receptor (FPR) in the protective action displayed by ANXA1 peptides. Administration of peptide Ac2-26 at 0, 30, and 60 min postreperfusion produced a significant protection against IR injury, and this was associated with reduced myeloperoxidase activity and IL-1beta levels in the infarcted heart. Western blotting and electron microscopy analyses showed that IR heart had increased ANXA1 expression in the injured tissue, associated mainly with the infiltrated leukocytes. Finally, an antagonist to the FPR receptor selectively inhibited the protective action of peptide ANXA1 and its derived peptides against IR injury. Altogether, these data provide further insight into the protective effect of ANXA1 and its mimetics and a rationale for a clinical use for drugs developed from this line of research.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Myocardial Reperfusion Injury  ISOAnxa1 (Rattus norvegicus)2306910; 2306910protein:increased expression:heart and leukocyteRGD 
Myocardial Reperfusion Injury  IEP 2306910protein:increased expression:heart and leukocyteRGD 

Objects Annotated

Genes (Rattus norvegicus)
Anxa1  (annexin A1)

Genes (Mus musculus)
Anxa1  (annexin A1)

Genes (Homo sapiens)
ANXA1  (annexin A1)


Additional Information