RGD Reference Report - A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression. - Rat Genome Database

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A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.

Authors: Heinzel, T  Lavinsky, RM  Mullen, TM  Soderstrom, M  Laherty, CD  Torchia, J  Yang, WM  Brard, G  Ngo, SD  Davie, JR  Seto, E  Eisenman, RN  Rose, DW  Glass, CK  Rosenfeld, MG 
Citation: Heinzel T, etal., Nature. 1997 May 1;387(6628):43-8.
RGD ID: 2306465
Pubmed: PMID:9139820   (View Abstract at PubMed)
DOI: DOI:10.1038/387043a0   (Journal Full-text)

Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of DNA-templated transcription  IMP 2306465 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ncor1  (nuclear receptor co-repressor 1)


Additional Information