A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
Authors:
Heinzel, T Lavinsky, RM Mullen, TM Soderstrom, M Laherty, CD Torchia, J Yang, WM Brard, G Ngo, SD Davie, JR Seto, E Eisenman, RN Rose, DW Glass, CK Rosenfeld, MG
Citation:
Heinzel T, etal., Nature. 1997 May 1;387(6628):43-8.
Transcriptional repression by nuclear receptors has been correlated to binding of the putative co-repressor, N-CoR. A complex has been identified that contains N-CoR, the Mad presumptive co-repressor mSin3, and the histone deacetylase mRPD3, and which is required for both nuclear receptor- and Mad-dependent repression, but not for repression by transcription factors of the ets-domain family. These data predict that the ligand-induced switch of heterodimeric nuclear receptors from repressor to activator functions involves the exchange of complexes containing histone deacetylases with those that have histone acetylase activity.