RGD Reference Report - Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats. - Rat Genome Database

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Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats.

Authors: Nagashima, A  Takano, Y  Tateishi, K  Matsuoka, Y  Hamaoka, T  Kamiya, H 
Citation: Nagashima A, etal., Brain Res. 1989 May 22;487(2):392-6.
RGD ID: 2305984
Pubmed: PMID:2471579   (View Abstract at PubMed)

Unilateral removal of the afferent fibers of the IXth and Xth cranial nerve (nodose ganglionectomy) caused significant decrease in the content of substance P-like immunoreactivity (SP-LI) and neurokinin A-like immunoreactivity (NKA-LI) in the nucleus tractus solitarii (NTS) of rats. Microinjection of SP (1 ng) or NKA (10-100 ng) into the NTS caused prompt, transient hypotension and bradycardia, suggesting that SP and NKA may be neurotransmitters of the baroreceptor reflex in the NTS. NKB-like immunoreactivity (NKB-LI) was also detected in the NTS of rats by radioimmunoassay, but its content in the NTS was not affected by unilateral nodose ganglionectomy. The microinjection of 1-10 ng of suc-[Asp5, Me-Phe8]-SP(6-11) (senktide, a selective neurokinin B receptor peptide) into the NTS caused long-lasting hypertension and tachycardia. These results indicate that NKB may also be a neuromodulator on cardiovascular responses in the NTS.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Bradycardia  ISOTac1 (Rattus norvegicus)2305984; 2305984 RGD 
Bradycardia  IDA 2305984 RGD 
hypertension  ISOTacr3 (Rattus norvegicus)2305984; 2305984 RGD 
hypertension  IDA 2305984 RGD 

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of heart rate  IDA 2305984 RGD 
positive regulation of heart rate  IDA 2305984 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tac1  (tachykinin, precursor 1)
Tacr3  (tachykinin receptor 3)

Genes (Mus musculus)
Tac1  (tachykinin 1)
Tacr3  (tachykinin receptor 3)

Genes (Homo sapiens)
TAC1  (tachykinin precursor 1)
TACR3  (tachykinin receptor 3)


Additional Information