Temporal trends of HLA genotype frequencies of type 1 diabetes patients in Sweden from 1986 to 2005 suggest altered risk.
Resic-Lindehammer, S Larsson, K Ortqvist, E Carlsson, A Cederwall, E Cilio, CM Ivarsson, SA Jonsson, BA Larsson, HE Lynch, K Neiderud, J Nilsson, A Sjoblad, S Lernmark, A Lernmark, A Aili, M Bååth, L E Carlsson, E Edenwall, H Forsander, G Granstro, B W Gustavsson, I Hanås, R Hellenberg, L Hellgren, H Holmberg, E Hörnell, H Ivarsson, Sten-A Johansson, C Jonsell, G Kockum, K Lindblad, B Lindh, A Ludvigsson, J Myrdal, U Neiderud, J Segnestam, K Sjöblad, S Skogsberg, L Strömberg, L Ståhle, U Thalme, B Tullus, K Tuvemo, T Wallensteen, M Westphal, O Aman, J
The aim of this study was to compare the frequency of human leukocyte antigen (HLA) genotypes in 1-18-year-old patients with type 1 diabetes newly diagnosed in 1986-1987 (n = 430), 1996-2000 (n = 342) and in 2003-2005 (n = 171). We tested the hypothesis that the HLA DQ genotype distribution changes over time. Swedish type 1 diabetes patients and controls were typed for HLA using polymerase chain reaction amplification and allele specific probes for DQ A1* and B1* alleles. The most common type 1 diabetes HLA DQA1*-B1*genotype 0501-0201/0301-0302 was 36% (153/430) in 1986-1987 and 37% (127/342) in 1996-2000, but decreased to 19% (33/171) in 2003-2005 (P < 0.0001). The 0501-0201/0501-0201 genotype increased from 1% in 1986-1987 to 7% in 1996-2000 (P = 0.0047) and to 5% in 2003-2005 (P > 0.05). This study in 1-18-year-old Swedish type 1 diabetes patients supports the notion that there is a temporal change in HLA risk.