RGD Reference Report - DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells. - Rat Genome Database

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DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells.

Authors: Carlsten, M  Bjorkstrom, NK  Norell, H  Bryceson, Y  Van Hall, T  Baumann, BC  Hanson, M  Schedvins, K  Kiessling, R  Ljunggren, HG  Malmberg, KJ 
Citation: Carlsten M, etal., Cancer Res. 2007 Feb 1;67(3):1317-25.
RGD ID: 2301336
Pubmed: PMID:17283169   (View Abstract at PubMed)
DOI: DOI:10.1158/0008-5472.CAN-06-2264   (Journal Full-text)

Although natural killer (NK) cells are well known for their ability to kill tumors, few studies have addressed the interactions between resting (nonactivated) NK cells and freshly isolated human tumors. Here, we show that human leukocyte antigen class I(low) tumor cells isolated directly from patients with advanced ovarian carcinoma trigger degranulation by resting allogeneic NK cells. This was paralleled by induction of granzyme B and caspase-6 activities in the tumor cells and significant tumor cell lysis. Ovarian carcinoma cells displayed ubiquitous expression of the DNAX accessory molecule-1 (DNAM-1) ligand PVR and sparse/heterogeneous expression of the NKG2D ligands MICA/MICB and ULBP1, ULBP2, and ULBP3. In line with the NK receptor ligand expression profiles, antibody-mediated blockade of activating receptor pathways revealed a dominant role for DNAM-1 and a complementary contribution of NKG2D signaling in tumor cell recognition. These results show that resting NK cells are capable of directly recognizing freshly isolated human tumor cells and identify ovarian carcinoma as a potential target for adoptive NK cell-based immunotherapy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ovarian carcinoma  IDA 2301336 RGD 
ovarian carcinoma  ISOCASP6 (Homo sapiens)2301336; 2301336 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp6  (caspase 6)

Genes (Mus musculus)
Casp6  (caspase 6)

Genes (Homo sapiens)
CASP6  (caspase 6)


Additional Information