RGD Reference Report - [A study on the time-dependent expression of caspase-6 during repair of skin contusion in rats] - Rat Genome Database

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[A study on the time-dependent expression of caspase-6 during repair of skin contusion in rats]

Authors: Peng, X  Guan, DW  Wang, Q 
Citation: Peng X, etal., Fa Yi Xue Za Zhi. 2007 Oct;23(5):325-7, 331.
RGD ID: 2301307
Pubmed: PMID:18175566   (View Abstract at PubMed)

OBJECTIVE: To investigate the expression of caspase-6 in rat skin contusion and its surrounding areas during repairment. METHODS: Immunohistochemical SP method and Western blot technique were used to study the expression and activation of caspase-6 in rat skin contusion and its surrounding areas. RESULTS: Weak expression of caspase-6 was detected in cytoplasms of polymorphonuchear cells (PMNs) infiltrated in the injured area at 3 hours post-contusion. The ratio of the caspase-6 positive cells was low (25.78 +/- 1.38)%. The expression of caspase-6 was increased prominently (47.70 +/- 5.14)% at 12 hours post-contusion. Almost all of the PMNs, mononuclear cells (MNCs) and fibroblastic cells (FBCs) were caspase-6 positive with both cytoplasm and nucleus staining (54.58 +/- 5.64)% on post-contusion day 3. The expression of caspase-6 decreased gradually thereafter. The expression of the 34-kDa pro-caspase-6 was detected by Western blot in both control and the post-contusion groups with time dependent dynamics. CONCLUSION: These results suggest that caspase-6 may play a major role in trauma-induced inflammatory response. Since caspase-6 shows a timely dependent expression in PMNs, MNCs and FBCs during skin injury repair in rat, it may be used as a marker for the contusion age determination,

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
acute inflammatory response to non-antigenic stimulus  IDA 2301307 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Casp6  (caspase 6)


Additional Information