RGD Reference Report - Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats. - Rat Genome Database

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Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats.

Authors: Adamovic, T  McAllister, D  Rowe, JJ  Wang, T  Jacob, HJ  Sugg, SL 
Citation: Adamovic T, etal., Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.
RGD ID: 2301186
Pubmed: PMID:18786441   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cancergencyto.2008.05.014   (Journal Full-text)

Identification of novel breast cancer susceptibility and resistance genes in genetically diverse human populations is challenging, and so inbred rats have been used to identify novel mammary cancer susceptibility quantitative trait loci (QTLs) with conventional mapping approaches. An alternative approach for QTL mapping is to use chromosome substitution (consomic) rat strains, which has the advantage of rapid generation of congenic from consomic animals. Using a novel rat strain pair, SS and BN, we identified rat mammary cancer QTLs in one of two consomic rat strains tested. Female rats of inbred parental (SS and BN) and two consomic (SS-10 BN and SS-12 BN) strains were treated with 7,12-dimethylbenz[a]anthracene orally. The phenotypes of tumor incidence, latency, and multiplicity were evaluated. SS rats were highly susceptible to mammary adenocarcinoma development, whereas BN rats were completely resistant. Statistical comparison of the phenotypes between the susceptible parental and the two consomic strains identified QTLs residing within chromosome 10 controlling mammary tumor latency and multiplicity. The study shows that SS-BN consomic rat strains can be used to map mammary tumor QTLs. This novel approach should accelerate positional cloning of mammary cancer susceptibility and resistant genes in the rat and the identification of homologous genes in humans.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Mammary Neoplasms inducedIAGP7,12-dimethyltetraphene (DMBA)2301186; 2301186 RGD 
Experimental Mammary Neoplasms inducedIAGP7,12-dimethyltetraphene (DMBA)2301186compared to BN/NHsdMcwiRGD 

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased incidence of tumors by chemical induction inducedIAGP7,12-dimethyltetraphene (DMBA)2301186compared to SS/JrHsdMcwiRGD 
decreased tumor latency inducedIAGP7,12-dimethyltetraphene (DMBA)2301186compared to SS/JrHsdMcwiRGD 
increased mammary adenocarcinoma incidence inducedIAGP7,12-dimethyltetraphene (DMBA)2301186; 2301186; 2301186compared to BN/NHsdMcwiRGD 
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