RGD Reference Report - Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis. - Rat Genome Database

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Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis.

Authors: Barbato, C  Corbi, N  Canu, N  Fanciulli, M  Serafino, A  Ciotti, M  Libri, V  Bruno, T  Amadoro, G  De Angelis, R  Calissano, P  Passananti, C 
Citation: Barbato C, etal., Mol Cell Neurosci. 2003 Dec;24(4):1038-50.
RGD ID: 2300214
Pubmed: PMID:14697667   (View Abstract at PubMed)

Che-1 is a recently identified human Rb binding protein that inhibits the Rb growth-suppressing function and regulates cell proliferation. Che-1 contacts the Rb and competes with HDAC1 for Rb-binding site, removing HDAC1 from the Rb/E2F cell cycle-regulated promoters. We have investigated the expression of Che-1 in neuronal cells and we showed that Che-1 directly interacts with Tau. Tau is a microtubule-associated protein involved in the assembly and stabilization of neuronal microtubules network that plays a crucial role modulating neuronal morphogenesis, axonal shape, and transport. In rat cerebellar granule neurons (CGNs) Che-1 partially colocalizes with Tau in the cytoplasm. Che-1 binds the amino-terminal region of Tau protein, which is not involved in microtubule interactions. Tau and Che-1 endogenous proteins coimmunoprecipitate from CGNs cellular lysates. In addition, Che-1/Tau interaction was demonstrated both in overexpressing COS-7 cells and CGNs by FRET analysis. Finally, we observed that Tau/Che-1 interaction is modulated during neuronal apoptosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein binding  IPIAatf (Rattus norvegicus)2300214 RGD 
tau protein binding  IPIMapt (Rattus norvegicus)2300214 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Aatf  (apoptosis antagonizing transcription factor)
Mapt  (microtubule-associated protein tau)


Additional Information