RGD Reference Report - Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer. - Rat Genome Database

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Antitumor activity of an immunotoxin in a nude mouse model of human ovarian cancer.

Authors: FitzGerald, DJ  Bjorn, MJ  Ferris, RJ  Winkelhake, JL  Frankel, AE  Hamilton, TC  Ozols, RF  Willingham, MC  Pastan, I 
Citation: FitzGerald DJ, etal., Cancer Res. 1987 Mar 1;47(5):1407-10.
RGD ID: 2298574
Pubmed: PMID:3493065   (View Abstract at PubMed)

An immunotoxin composed of an antibody to the human transferrin receptor (454A12) and ricin A chain (RTA) was shown to inhibit the growth of NIH:OVCAR-3 tumors in a nude mouse model of human ovarian cancer. Inhibition of tumor growth by 454A12-RTA was related to the dose administered. The antitumor activity of the immunotoxin was blocked by coinjection of excess antibody with immunotoxin. An immunotoxin made using 454A12 and recombinant ricin A chain (rRTA) had an activity similar to that made with native RTA. The administration of 10 micrograms or greater of the immunotoxin 454A12-RTA/rRTA had significant antitumor activity. The injection of 30 micrograms of an irrelevant immunotoxin, MOPC21-RTA, or 30 to 500 micrograms of the 454A12 antibody had no antitumor activity.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ovarian cancer  IMP 2298574 RGD 
ovarian cancer  ISOTFRC (Homo sapiens)2298574; 2298574 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tfrc  (transferrin receptor)

Genes (Mus musculus)
Tfrc  (transferrin receptor)

Genes (Homo sapiens)
TFRC  (transferrin receptor)


Additional Information