RGD Reference Report - Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice. - Rat Genome Database

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Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level: a study on hCG overexpressing transgenic mice.

Authors: Ahtiainen, P  Rulli, SB  Shariatmadari, R  Pelliniemi, LJ  Toppari, J  Poutanen, M  Huhtaniemi, IT 
Citation: Ahtiainen P, etal., Oncogene. 2005 Nov 10;24(49):7301-9.
RGD ID: 2293633
Pubmed: PMID:16007123   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.onc.1208893   (Journal Full-text)

We have previously demonstrated that male transgenic (TG) mice overexpressing human chorionic gonadotropin (hCG+) develop reproductive organ defects, but no tumors, in adult age. In this study, the effects of persistently elevated hCG were followed in TG males between day 5 postpartum and adulthood. Leydig cell (LC) adenomas were found in prepubertal mice, most prominently at the age of 10 days, but not in adult age. Serum testosterone concentrations were significantly increased in TG males at all ages studied. The phenotype of the prepubertal hCG+ males resembled that found in boys upon expression of constitutively activating luteinizing hormone (LH) receptor mutations. The temporal expression patterns of the fetal LC marker gene, thrombospondin 2, and those of adult LCs, hydroxysteroid dehydrogenase-6, delta5-3-beta and prostaglandin D synthase, were similar in wild-type and hCG+ males. Hence, the postnatal adenomas resemble functionally fetal LCs, and only these cells are susceptible to hCG-induced tumorigenesis. Our findings demonstrate a novel intriguing difference between the fetal and adult LC populations and provide further insight into the potential tumorigenic effects of gonadotropins.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Leydig cell tumor  IEP 2293633 RGD 
Leydig cell tumor  ISOCGA (Homo sapiens)2293633; 2293633 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cga  (glycoprotein hormones, alpha polypeptide)

Genes (Mus musculus)
Cga  (glycoprotein hormones, alpha subunit)

Genes (Homo sapiens)
CGA  (glycoprotein hormones, alpha polypeptide)


Additional Information