RGD Reference Report - Context and strain-dependent behavioral response to stress. - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

Context and strain-dependent behavioral response to stress.

Authors: Nosek, K  Dennis, K  Andrus, BM  Ahmadiyeh, N  Baum, AE  Solberg Woods, LC  Redei, EE 
Citation: Nosek K, etal., Behav Brain Funct. 2008 Jun 2;4(1):23.
RGD ID: 2293622
Pubmed: PMID:18518967   (View Abstract at PubMed)
PMCID: PMC2424057   (View Article at PubMed Central)
DOI: DOI:10.1186/1744-9081-4-23   (Journal Full-text)

ABSTRACT: BACKGROUND: This study posed the question whether strain differences in stress-reactivity lead to differential behavioral responses in two different tests of anxiety. Strain differences in anxiety-measures are known, but strain differences in the behavioral responses to acute prior stress are not well characterized. METHODS: We studied male Fischer 344 (F344) and Wistar Kyoto (WKY) rats basally and immediately after one hour restraint stress. To distinguish between the effects of novelty and prior stress, we also investigated behavior after repeated exposure to the test chamber. Two behavioral tests were explored; the elevated plus maze (EPM) and the open field (OFT), both of which are thought to measure activity, exploration and anxiety-like behaviors. Additionally, rearing, a voluntary behavior, and grooming, a relatively automatic, stress-responsive stereotyped behavior were measured in both tests. RESULTS: Prior exposure to the test environment increased anxiety-related measures regardless of prior stress, reflecting context-dependent learning process in both tests and strains. Activity decreased in response to repeated testing in both tests and both strains, but prior stress decreased activity only in the OFT which was reversed by repeated testing. Prior stress decreased anxiety-related measures in the EPM, only in F344's, while in the OFT, stress led to increased freezing mainly in WKYs. CONCLUSIONS: Data suggest that differences in stressfulness of these tests predict the behavior of the two strains of animals according to their stress-reactivity and coping style, but that repeated testing can overcome some of these differences.

Phenotype Annotations    Click to see Annotation Detail View

Mammalian Phenotype

TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
decreased anxiety-related response  IAGP 2293622compared to F344/NHsdRGD 
decreased grooming behavior inducedIAGPphysical restraint2293622compared to F344/NHsdRGD 
decreased locomotor activity inducedIAGPphysical restraint2293622compared to F344/NHsdRGD 
decreased vertical activity  IAGP 2293622compared to F344/NHsdRGD 
hyperactivity  IAGP 2293622as compared to WKY/NHsdRGD 
increased anxiety-related response  IAGP 2293622as compared to WKY/NHsdRGD 
increased grooming behavior  IAGP 2293622as compared to WKY/NHsdRGD 
Objects Annotated

Strains
F344/NHsd  (F344/NHsd)
WKY/NHsd  (NA)


Additional Information