RGD Reference Report - T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model. - Rat Genome Database

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T-cadherin supports angiogenesis and adiponectin association with the vasculature in a mouse mammary tumor model.

Authors: Hebbard, LW  Garlatti, M  Young, LJ  Cardiff, RD  Oshima, RG  Ranscht, B 
Citation: Hebbard LW, etal., Cancer Res. 2008 Mar 1;68(5):1407-16.
RGD ID: 2293540
Pubmed: PMID:18316604   (View Abstract at PubMed)
PMCID: PMC2676344   (View Article at PubMed Central)
DOI: DOI:10.1158/0008-5472.CAN-07-2953   (Journal Full-text)

T-cadherin delineates endothelial, myoepithelial, and ductal epithelial cells in the normal mouse mammary gland, and becomes progressively restricted to the vasculature during mammary tumorigenesis. To test the function of T-cadherin in breast cancer, we inactivated the T-cadherin (Cdh13) gene in mice and evaluated tumor development and pathology after crossing the mutation into the mouse mammary tumor virus (MMTV)-polyoma virus middle T (PyV-mT) transgenic model. We report that T-cadherin deficiency limits mammary tumor vascularization and reduces tumor growth. Tumor transplantation experiments confirm the stromal role of T-cadherin in tumorigenesis. In comparison with wild-type MMTV-PyV-mT controls, T-cadherin-deficient tumors are pathologically advanced and metastasize to the lungs. T-cadherin is a suggested binding partner for high molecular weight forms of the circulating, fat-secreted hormone adiponectin. We discern adiponectin in association with the T-cadherin-positive vasculature in the normal and malignant mammary glands and report that this interaction is lost in the T-cadherin null condition. This work establishes a role for T-cadherin in promoting tumor angiogenesis and raises the possibility that vascular T-cadherin-adiponectin association may contribute to the molecular cross-talk between tumor cells and the stromal compartment in breast cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Experimental Mammary Neoplasms  ISOCdh13 (Mus musculus)2293540; 2293540 RGD 
Experimental Mammary Neoplasms severityIAGP 2293540 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdh13  (cadherin 13)

Genes (Mus musculus)
Cdh13  (cadherin 13)

Genes (Homo sapiens)
CDH13  (cadherin 13)


Additional Information