RGD Reference Report - Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. - Rat Genome Database

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Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma.

Authors: Mishima, K  Kato, Y  Kaneko, MK  Nakazawa, Y  Kunita, A  Fujita, N  Tsuruo, T  Nishikawa, R  Hirose, T  Matsutani, M 
Citation: Mishima K, etal., Acta Neuropathol. 2006 Jun;111(6):563-8. Epub 2006 May 5.
RGD ID: 2292236
Pubmed: PMID:16718353   (View Abstract at PubMed)
DOI: DOI:10.1007/s00401-006-0033-4   (Journal Full-text)

Podoplanin, a mucin-like transmembrane sialoglycoprotein, promotes platelet aggregation and may be involved in cancer cell migration, invasion, metastasis, and malignant progression. Podoplanin/aggrus is highly expressed in testicular seminoma, suggesting that it may be a sensitive marker for testicular seminomas. Here we investigated the expression of podoplanin in central nervous system (CNS) germ cell tumors (GCTs) by immunohistochemical staining of tumor samples from 62 patients. In 40 of 41 (98%) germinomas (including germinomatous components in mixed GCTs), podoplanin was diffusely expressed on the surface of germinoma cells; lymphocytes, interstitial cells, and syncytiotrophoblastic giant cells were negative for podoplanin. Except for immature teratomas (12/17; 71%), podoplanin expression was absent in non-germinomatous GCTs, including seven teratomas, seven embryonal carcinomas, seven yolk sac tumors, and seven choriocarcinomas. In immature teratomas, focal podoplanin staining was observed in fewer than 10% of immature squamous and columnar epithelial cells. Thus, podoplanin expression may be a sensitive immunohistochemical marker for germinoma in CNS GCTs. As such, it may be useful for diagnosis, for monitoring the efficacy of treatment, and as a potential target for antibody-based therapy.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
germinoma  IEP 2292236 RGD 
germinoma  ISOPDPN (Homo sapiens)2292236; 2292236 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Pdpn  (podoplanin)

Genes (Mus musculus)
Pdpn  (podoplanin)

Genes (Homo sapiens)
PDPN  (podoplanin)


Additional Information