RGD Reference Report - Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. - Rat Genome Database

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Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury.

Authors: Boulos, S  Meloni, BP  Arthur, PG  Bojarski, C  Knuckey, NW 
Citation: Boulos S, etal., J Neurosci Res. 2007 Nov 1;85(14):3089-97.
RGD ID: 2291829
Pubmed: PMID:17663478   (View Abstract at PubMed)
DOI: DOI:10.1002/jnr.21429   (Journal Full-text)

We previously reported that peroxiredoxin 2 (PRDX2) and Cu/Zn superoxide dismutase 1 (SOD1) proteins are up-regulated in rat primary neuronal cultures following erythropoietin (EPO) preconditioning. In the present study, we have demonstrated that adenovirally mediated overexpression of PRDX2 in cortical neuronal cultures can protect neurons from in vitro ischemia (oxygen-glucose deprivation) and an oxidative insult (cumene hydroperoxide) but not glutamate excitotoxicity. We have also demonstrated that adenovirally mediated overexpression of SOD1 in cortical neuronal cultures protected neurons only against the oxidative insult. Interestingly, we did not detect up-regulation of PRDX2 or SOD1 protein in the rat hippocampus following exposure to either 3 min or 8 min of global cerebral ischemia. Further characterization of PRDX2's neuroprotective mechanisms may aid in the development of a neuroprotective therapy.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of neuron apoptotic process  IMP 2291829 RGD 
response to oxidative stress  IMP 2291829; 2291829 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Prdx2  (peroxiredoxin 2)
Sod1  (superoxide dismutase 1)


Additional Information