RGD Reference Report - Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma. - Rat Genome Database

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Overexpression of the p53 protein and allele loss at 17p13 in ovarian carcinoma.

Authors: Eccles, DM  Brett, L  Lessells, A  Gruber, L  Lane, D  Steel, CM  Leonard, RC 
Citation: Eccles DM, etal., Br J Cancer. 1992 Jan;65(1):40-4.
RGD ID: 2290540
Pubmed: PMID:1310251   (View Abstract at PubMed)
PMCID: PMC1977350   (View Article at PubMed Central)

Mouse monoclonal antibodies PAb 240 and PAb 1801 which specifically immunoprecipitate p53 protein, were used to examine 27 fresh ovarian tumours (16 serous adenocarcinomas, six endometrioid carcinomas, one mucinous adenocarcinoma, one mucinous borderline tumour and three benign adenomas). Eleven out of 16 (69%) serous adenocarcinomas and one endometrioid tumour showed positive staining with one or both antibodies and none of the mucinous or benign tumours stained with either antibody. DNA from tumour and peripheral blood leukocytes was used to identify allelic deletions on chromosome 17p in tumours. 11/12 positively staining tumours showed less of heterozygosity (LOH) on 17p at the nearest informative locus to the p53 gene. In this series of ovarian tumours, LOH on 17p correlates closely with the aberrant expression of the p53 protein in a high proportion of advanced stage serous adenocarcinomas. This observation suggests that the p53 tumour suppressor gene is involved in the evolution of epithelial ovarian cancer (EOC) and may have prognostic significance.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ovary serous adenocarcinoma  IDA 2290540DNA more ...RGD 
ovary serous adenocarcinoma  ISOTP53 (Homo sapiens)2290540; 2290540DNA more ...RGD 

Objects Annotated

Genes (Rattus norvegicus)
Tp53  (tumor protein p53)

Genes (Mus musculus)
Trp53  (transformation related protein 53)

Genes (Homo sapiens)
TP53  (tumor protein p53)


Additional Information