RGD Reference Report - Wei sheng yan jiu = Journal of hygiene research - Rat Genome Database

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Wei sheng yan jiu = Journal of hygiene research

Authors: Xu, J  Liu, X  Yang, X  Li, L  Et, AL 
Citation: Xu J, etal., Wei Sheng Yan Jiu. 2007 Jul;36(4):443-5.
RGD ID: 2290173
Pubmed: PMID:17953211   (View Abstract at PubMed)

OBJECTIVE: To explore the mechanism of iodine over-treatment to FRTL cell on the cell apoptosis through observing the cell apoptosis related gene. METHODS: The cells were treated with potassium iodide (0, 5, 10, 50 and 100mmol/L). After treatment 24 hours, the cells were collected and analyzed by flow cytometry. The mRNA levels of fas, fasL, Bcl-2 and Bax of 50mmol/L and 100mmol/L groups were determined with real-time PCR. RESULTS: Compared with the normal control group, the rates of cell apoptosis of 10, 50 and 100mmol/L iodine groups increased significantly. Compared with the normal control group, the mRNA levels of fasL and Bax in 10 and 50mmol/L iodine groups increased significantly while the level of Bcl-2 decreased significantly. There was no significant difference fas mRNA levels between the normal control group and 10mmol/L iodine group, but the fas mRNA level in 50mmol/L iodine group increased significantly. CONCLUSION: The excessive iodine treatment increased the apoptosis of FRTL cells which might be related to gene expressions of fas, fasL, Bcl-2 and Bax.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
response to inorganic substance  IEP 2290173 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fas  (Fas cell surface death receptor)


Additional Information