RGD Reference Report - Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system. - Rat Genome Database

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Generation of rat mutants using a coat color-tagged Sleeping Beauty transposon system.

Authors: Lu, B  Geurts, AM  Poirier, C  Petit, DC  Harrison, W  Overbeek, PA  Bishop, CE 
Citation: Lu B, etal., Mamm Genome. 2007 May;18(5):338-46. Epub 2007 Jun 8.
RGD ID: 2290040
Pubmed: PMID:17557177   (View Abstract at PubMed)
DOI: DOI:10.1007/s00335-007-9025-5   (Journal Full-text)

A significant barrier to exploiting the full potential of the rat as a biomedical model is the lack of tools to easily modify its germline. Here we show that a tyrosinase-tagged Sleeping Beauty transposon can be used as a simple, efficient method to generate rat mutants in vivo. By making two lines of transgenic rats, one carrying the transposon and another expressing the transposase in germ cells, we are able to obtain bigenic males in which transposition occurs in the germ cells. We show that transposition leads to the appearance of new coat colors in the offspring. Using such bigenic males, we obtained an average of 1.2 transpositions per gamete and identified 19 intragenic integration events among 96 transposition sites that were sequenced. In addition, gene trapping was confirmed and rats with evidence for transposon-induced dominant ocular anomalies were identified. These data suggest that the modified Sleeping Beauty transposon represents a powerful new tool for producing molecularly defined mutagenesis in the rat.

Objects referenced in this article
Gene AbatTn(sb-T2/Bart3)2.163Mcwi 4-aminobutyrate aminotransferase; transposon insertion 2.163, Medical College of Wisconsin Rattus norvegicus
Gene AcoxlTn(sb-T2/Bart3)2.342Mcwi acyl-Coenzyme A oxidase-like; transposon insertion 2.342, Medical College of Wisconsin Rattus norvegicus
Gene AdaTn(sb-T2/Bart3)2.237Mcwi adenosine deaminase; transposon insertion 2.237, Medical College of Wisconsin Rattus norvegicus
Gene Adgrl3Tn(sb-T2/Bart3)2.151Mcwi adhesion G protein-coupled receptor L3; transposon insertion 2.151, Medical College of Wisconsin Rattus norvegicus
Gene Agbl4Tn(sb-T2/Bart3)2.337Mcwi ATP/GTP binding protein-like 4; transposon insertion 2.337, Medical College of Wisconsin Rattus norvegicus
Gene Ano3Tn(sb-T2/Bart3)2.307Mcwi anoctamin 3; transposon insertion 2.307, Medical College of Wisconsin Rattus norvegicus
Gene Auts2Tn(sb-T2/Bart3)2.344Mcwi autism susceptibility candidate 2; transposon insertion 2.344, Medical College of Wisconsin Rattus norvegicus
Gene AW527406Tn(sb-T2/Bart3)2.156Mcwi EST AW527406; transposon insertion 2.156, Medical College of Wisconsin Rattus norvegicus
Gene AW915325Tn(sb-T2/Bart3)2.319Mcwi EST AW915325; transposon insertion 2.319, Medical College of Wisconsin Rattus norvegicus
Gene AW921689Tn(sb-T2/Bart3)2.209Mcwi EST AW921689; transposon insertion 2.209, Medical College of Wisconsin Rattus norvegicus
Gene BbxTn(sb-T2/Bart3)2.291Mcwi bobby sox homolog (Drosophila); transposon insertion 2.291, Medical College of Wisconsin Rattus norvegicus
Gene BE329202Tn(sb-T2/Bart3)2.198Mcwi EST BE329202; transposon insertion 2.198, Medical College of Wisconsin Rattus norvegicus
Gene BF522453Tn(sb-T2/Bart3)2.166Mcwi EST BF522453; transposon insertion 2.166, Medical College of Wisconsin Rattus norvegicus
Gene BI284934Tn(sb-T2/Bart3)2.185Mcwi EST BI284934; transposon insertion 2.185, Medical College of Wisconsin Rattus norvegicus
Gene BI284938Tn(sb-T2/Bart3)2.155Mcwi EST BI284938; transposon insertion 2.155, Medical College of Wisconsin Rattus norvegicus
Gene BI284938Tn(sb-T2/Bart3)2.187Mcwi EST BI284938; transposon insertion 2.187, Medical College of Wisconsin Rattus norvegicus
Gene BI285110Tn(sb-T2/Bart3)2.167Mcwi EST BI285110; transposon insertion 2.167, Medical College of Wisconsin Rattus norvegicus
Gene BI285226Tn(sb-T2/Bart3)2.193Mcwi EST BI285226; transposon insertion 2.193, Medical College of Wisconsin Rattus norvegicus
Gene BI285226Tn(sb-T2/Bart3)2.194Mcwi EST BI285226; transposon insertion 2.194, Medical College of Wisconsin Rattus norvegicus
Gene BQ195794Tn(sb-T2/Bart3)2.182Mcwi EST BQ195794; transposon insertion 2.182, Medical College of Wisconsin Rattus norvegicus
Gene Brinp3Tn(sb-T2/Bart3)2.189Mcwi BMP/retinoic acid-inducible neural-specific protein 3; transposon insertion 2.189, Medical College of Wisconsin Rattus norvegicus
Gene CA338503Tn(sb-T2/Bart3)2.168Mcwi EST CA338503; transposon insertion 2.168, Medical College of Wisconsin Rattus norvegicus
Gene CA338503Tn(sb-T2/Bart3)2.175Mcwi EST CA338503; transposon insertion 2.175, Medical College of Wisconsin Rattus norvegicus
Gene CA338503Tn(sb-T2/Bart3)2.196Mcwi EST CA338503; transposon insertion 2.196, Medical College of Wisconsin Rattus norvegicus
Gene Cadm1Tn(sb-T2/Bart3)2.229Mcwi cell adhesion molecule 1; transposon insertion 2.229, Medical College of Wisconsin Rattus norvegicus
Gene Cadm2Tn(sb-T2/Bart3)2.180Mcwi immunoglobulin superfamily, member 4 ; transposon insertion 2.180, Medical College of Wisconsin Rattus norvegicus
Gene Casp7Tn(sb-T2/Bart3)2.280Mcwi caspase 7; transposon insertion 2.280, Medical College of Wisconsin Rattus norvegicus
Gene CB706876Tn(sb-T2/Bart3)2.181Mcwi EST CB706876; transposon insertion 2.181, Medical College of Wisconsin Rattus norvegicus
Gene Ccdc85aTn(sb-T2/Bart3)2.248Mcwi coiled-coil domain containing 85A; transposon insertion 2.248, Medical College of Wisconsin Rattus norvegicus
Gene Cd226Tn(sb-T2/Bart3)2.141Mcwi CD226 antigen; transposon insertion 2.141, Medical College of Wisconsin Rattus norvegicus
Gene Chsy1Tn(sb-T2/Bart3)2.165Mcwi carbohydrate (chondroitin) synthase 1 ; transposon insertion 2.165, Medical College of Wisconsin Rattus norvegicus
Gene Csmd3Tn(sb-T2/Bart3)2.288Mcwi CUB and Sushi multiple domains 3; transposon insertion 2.288, Medical College of Wisconsin Rattus norvegicus
Gene Cst3Tn(sb-T2/Bart3)2.172Mcwi cystatin C; transposon insertion 2.172, Medical College of Wisconsin Rattus norvegicus
Gene Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi cytochrome P450, family 7, subfamily b, polypeptide 1; transposon insertion 2.306, Medical College of Wisconsin Rattus norvegicus
Gene CyssTn(sb-T2/Bart3)2.173Mcwi cystatin S; transposon insertion 2.173, Medical College of Wisconsin Rattus norvegicus
Gene Cyyr1Tn(sb-T2/Bart3)2.328Mcwi cysteine/tyrosine-rich 1; transposon insertion 2.328, Medical College of Wisconsin Rattus norvegicus
Gene DccTn(sb-T2/Bart3)2.205Mcwi deleted in colorectal carcinoma; transposon insertion 2.205, Medical College of Wisconsin Rattus norvegicus
Gene Diaph3Tn(sb-T2/Bart3)2.318Mcwi diaphanous homolog 3 (Drosophila); transposon insertion 2.318, Medical College of Wisconsin Rattus norvegicus
Gene Dlg1Tn(sb-T2/Bart3)2.133Mcwi discs, large homolog 1 (Drosophila); transposon insertion 2.133, Medical College of Wisconsin Rattus norvegicus
Gene Dnah11Tn(sb-T2/Bart3)2.293Mcwi dynein, axonemal, heavy chain 11; transposon insertion 2.293, Medical College of Wisconsin Rattus norvegicus
Gene Dnhd1Tn(sb-T2/Bart3)2.243Mcwi dynein heavy chain domain 1; transposon insertion 2.243, Medical College of Wisconsin Rattus norvegicus
Gene Dzank1Tn(sb-T2/Bart3)2.164Mcwi double zinc ribbon and ankyrin repeat domains 1; transposon insertion 2.164, Medical College of Wisconsin Rattus norvegicus
Gene Elmod3Tn(sb-T2/Bart3)2.42Mcwi RNA binding motif and ELMO domain 1; transposon insertion 1.42, Medical College of Wisconsin Rattus norvegicus
Gene Enox1Tn(sb-T2/Bart3)2.282Mcwi ecto-NOX disulfide-thiol exchanger 1; transposon insertion 2.282, Medical College of Wisconsin Rattus norvegicus
Gene Entpd6Tn(sb-T2/Bart3)2.174Mcwi ectonucleoside triphosphate diphosphohydrolase 6; transposon insertion 2.174, Medical College of Wisconsin Rattus norvegicus
Gene Erbb4Tn(sb-T2/Bart3)2.208Mcwi v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian); transposon insertion 2.208, Medical College of Wisconsin Rattus norvegicus
Gene Eva1aTn(sb-T2/Bart3)2.233Mcwi eva-1 homolog A, regulator of programmed cell death; transposon insertion 2.233, Medical College of Wisconsin Rattus norvegicus
Gene Exoc4Tn(sb-T2/Bart3)2.317Mcwi exocyst complex component 4; transposon insertion 2.317, Medical College of Wisconsin Rattus norvegicus
Strain F344-AbatTn(sb-T2/Bart3)2.163Mcwi null Rattus norvegicus
Strain F344-AcoxlTn(sb-T2/Bart3)2.342Mcwi null Rattus norvegicus
Strain F344-AdaTn(sb-T2/Bart3)2.237Mcwi null Rattus norvegicus
Strain F344-Adgrl3Tn(sb-T2/Bart3)2.151Mcwi null Rattus norvegicus
Strain F344-Agbl4Tn(sb-T2/Bart3)2.337Mcwi null Rattus norvegicus
Strain F344-Ano3Tn(sb-T2/Bart3)2.307Mcwi null Rattus norvegicus
Strain F344-Auts2Tn(sb-T2/Bart3)2.344Mcwi null Rattus norvegicus
Strain F344-AW527406Tn(sb-T2/Bart3)2.156Mcwi null Rattus norvegicus
Strain F344-AW921689Tn(sb-T2/Bart3)2.209Mcwi null Rattus norvegicus
Strain F344-BbxTn(sb-T2/Bart3)2.291Mcwi null Rattus norvegicus
Strain F344-BE329202Tn(sb-T2/Bart3)2.198Mcwi null Rattus norvegicus
Strain F344-BF522453Tn(sb-T2/Bart3)2.166Mcwi null Rattus norvegicus
Strain F344-BI284934Tn(sb-T2/Bart3)2.185Mcwi null Rattus norvegicus
Strain F344-BI284938Tn(sb-T2/Bart3)2.155Mcwi null Rattus norvegicus
Strain F344-BI284938Tn(sb-T2/Bart3)2.187Mcwi null Rattus norvegicus
Strain F344-BI285110Tn(sb-T2/Bart3)2.167Mcwi null Rattus norvegicus
Strain F344-BI285226Tn(sb-T2/Bart3)2.193Mcwi null Rattus norvegicus
Strain F344-BI285226Tn(sb-T2/Bart3)2.194Mcwi null Rattus norvegicus
Strain F344-BQ195794Tn(sb-T2/Bart3)2.182Mcwi null Rattus norvegicus
Strain F344-Brinp3Tn(sb-T2/Bart3)2.189Mcwi null Rattus norvegicus
Strain F344-CA338503Tn(sb-T2/Bart3)2.168Mcwi null Rattus norvegicus
Strain F344-CA338503Tn(sb-T2/Bart3)2.175Mcwi null Rattus norvegicus
Strain F344-CA338503Tn(sb-T2/Bart3)2.196Mcwi null Rattus norvegicus
Strain F344-Cadm1Tn(sb-T2/Bart3)2.229Mcwi null Rattus norvegicus
Strain F344-Cadm2Tn(sb-T2/Bart3)2.180Mcwi null Rattus norvegicus
Strain F344-Casp7Tn(sb-T2/Bart3)2.280Mcwi null Rattus norvegicus
Strain F344-CB706876Tn(sb-T2/Bart3)2.181Mcwi null Rattus norvegicus
Strain F344-Ccdc85aTn(sb-T2/Bart3)2.248Mcwi null Rattus norvegicus
Strain F344-Cd226Tn(sb-T2/Bart3)2.141Mcwi null Rattus norvegicus
Strain F344-Chsy1Tn(sb-T2/Bart3)2.165Mcwi null Rattus norvegicus
Strain F344-Csmd3Tn(sb-T2/Bart3)2.288Mcwi null Rattus norvegicus
Strain F344-Cst3Tn(sb-T2/Bart3)2.172Mcwi null Rattus norvegicus
Strain F344-Cyp7b1Tn(sb-T2/Bart3)2.306Mcwi null Rattus norvegicus
Strain F344-CyssTn(sb-T2/Bart3)2.173Mcwi null Rattus norvegicus
Strain F344-Cyyr1Tn(sb-T2/Bart3)2.328Mcwi null Rattus norvegicus
Strain F344-DccTn(sb-T2/Bart3)2.205Mcwi null Rattus norvegicus
Strain F344-Diaph3Tn(sb-T2/Bart3)2.318Mcwi null Rattus norvegicus
Strain F344-Dlg1Tn(sb-T2/Bart3)2.133Mcwi null Rattus norvegicus
Strain F344-Dnah11Tn(sb-T2/Bart3)2.293Mcwi null Rattus norvegicus
Strain F344-Dnhd1Tn(sb-T2/Bart3)2.243Mcwi null Rattus norvegicus
Strain F344-Dzank1Tn(sb-T2/Bart3)2.164Mcwi null Rattus norvegicus
Strain F344-Elmod3Tn(sb-T2/Bart3)2.42Mcwi null Rattus norvegicus
Strain F344-Enox1Tn(sb-T2/Bart3)2.282Mcwi null Rattus norvegicus
Strain F344-Entpd6Tn(sb-T2/Bart3)2.174Mcwi null Rattus norvegicus
Strain F344-Erbb4Tn(sb-T2/Bart3)2.208Mcwi null Rattus norvegicus
Strain F344-Eva1aTn(sb-T2/Bart3)2.233Mcwi null Rattus norvegicus
Strain F344-Exoc4Tn(sb-T2/Bart3)2.317Mcwi null Rattus norvegicus
Strain F344-Fam19a2Tn(sb-T2/Bart3)2.184Mcwi null Rattus norvegicus
Strain F344-Fam227aTn(sb-T2/Bart3)2.333Mcwi null Rattus norvegicus
Strain F344-FaslgTn(sb-T2/Bart3)2.325Mcwi null Rattus norvegicus
Strain F344-FM117003Tn(sb-T2/Bart3)2.321McwiRrrc null Rattus norvegicus
Strain F344-Galntl6Tn(sb-T2/Bart3)2.311McwiRrrc null Rattus norvegicus
Strain F344-Glis1Tn(sb-T2/Bart3)2.149Mcwi null Rattus norvegicus
Strain F344-Gng12Tn(sb-T2/Bart3)2.320Mcwi null Rattus norvegicus
Strain F344-Gramd1bTn(sb-T2/Bart3)2.287Mcwi null Rattus norvegicus
Strain F344-Grk1Tn(sb-T2/Bart3)2.234Mcwi null Rattus norvegicus
Strain F344-Immp1lTn(sb-T2/Bart3)2.246Mcwi null Rattus norvegicus
Strain F344-Inpp4bTn(sb-T2/Bart3)2.143Mcwi null Rattus norvegicus
Strain F344-Inpp4bTn(sb-T2/Bart3)2.232Mcwi null Rattus norvegicus
Strain F344-IntuTn(sb-T2/Bart3)2.324Mcwi null Rattus norvegicus
Strain F344-Kcnab1Tn(sb-T2/Bart3)2.300Mcwi null Rattus norvegicus
Strain F344-Kcnh7Tn(sb-T2/Bart3)2.295Mcwi null Rattus norvegicus
Strain F344-Kcnip4Tn(sb-T2/Bart3)2.225Mcwi null Rattus norvegicus
Strain F344-Kif16bTn(sb-T2/Bart3)2.200Mcwi null Rattus norvegicus
Strain F344-Klhl13Tn(sb-T2/Bart3)2.176Mcwi null Rattus norvegicus
Strain F344-Klra1Tn(sb-T2/Bart3)2.279Mcwi null Rattus norvegicus
Strain F344-Lama2Tn(sb-T2/Bart3)2.2013Mcwi null Rattus norvegicus
Strain F344-LargeTn(sb-T2/Bart3)2.336Mcwi null Rattus norvegicus
Strain F344-Lims1Tn(sb-T2/Bart3)2.169Mcwi null Rattus norvegicus
Strain F344-LmlnTn(sb-T2/Bart3)2.322Mcwi null Rattus norvegicus
Strain F344-LOC290071Tn(sb-T2/Bart3)2.170Mcwi null Rattus norvegicus
Strain F344-LOC681893Tn(sb-T2/Bart3)2.159Mcwi null Rattus norvegicus
Strain F344-LOC681893Tn(sb-T2/Bart3)2.161Mcwi null Rattus norvegicus
Strain F344-Lrrc4cTn(sb-T2/Bart3)2.224Mcwi null Rattus norvegicus
Strain F344-Lrrc4cTn(sb-T2/Bart3)2.254Mcwi null Rattus norvegicus
Strain F344-Lrrc7Tn(sb-T2/Bart3)2.253Mcwi null Rattus norvegicus
Strain F344-LzicTn(sb-T2/Bart3)2.309Mcwi null Rattus norvegicus
Strain F344-Map2k5Tn(sb-T2/Bart3)2.150Mcwi null Rattus norvegicus
Strain F344-Mgat4cTn(sb-T2/Bart3)2.244Mcwi null Rattus norvegicus
Strain F344-Mmel1Tn(sb-T2/Bart3)2.255Mcwi null Rattus norvegicus
Strain F344-Mov10Tn(sb-T2/Bart3)2.281Mcwi null Rattus norvegicus
Strain F344-Myo1dTn(sb-T2/Bart3)2.334Mcwi null Rattus norvegicus
Strain F344-Myo9aTn(sb-T2/Bart3)2.186Mcwi null Rattus norvegicus
Strain F344-NapbTn(sb-T2/Bart3)2.162Mcwi null Rattus norvegicus
Strain F344-Nectin1Tn(sb-T2/Bart3)2.284Mcwi null Rattus norvegicus
Strain F344-Nell1Tn(sb-T2/Bart3)2.195Mcwi null Rattus norvegicus
Strain F344-Nrg1Tn(sb-T2/Bart3)2.183Mcwi null Rattus norvegicus
Strain F344-Nrxn2Tn(sb-T2/Bart3)2.250Mcwi null Rattus norvegicus
Strain F344-Nsun4Tn(sb-T2/Bart3)2.286Mcwi null Rattus norvegicus
Strain F344-NtmTn(sb-T2/Bart3)2.130Mcwi null Rattus norvegicus
Strain F344-Orc3Tn(sb-T2/Bart3)2.275Mcwi null Rattus norvegicus
Strain F344-P3h3Tn(sb-T2/Bart3)2.310Mcwi null Rattus norvegicus
Strain F344-PalldTn(sb-T2/Bart3)2.341Mcwi null Rattus norvegicus
Strain F344-PatjTn(sb-T2/Bart3)2.343Mcwi null Rattus norvegicus
Strain F344-Pde4dTn(sb-T2/Bart3)2.285Mcwi null Rattus norvegicus
Strain F344-Pde5aTn(sb-T2/Bart3)2.144Mcwi null Rattus norvegicus
Strain F344-Pebp4Tn(sb-T2/Bart3)2.299Mcwi null Rattus norvegicus
Strain F344-Plcb3Tn(sb-T2/Bart3)2.69Mcwi null Rattus norvegicus
Strain F344-Plce1Tn(sb-T2/Bart3)2.146Mcwi null Rattus norvegicus
Strain F344-Pld5Tn(sb-T2/Bart3)2.340Mcwi null Rattus norvegicus
Strain F344-Ppapdc1aTn(sb-T2/Bart3)2.207Mcwi null Rattus norvegicus
Strain F344-Ppfia2Tn(sb-T2/Bart3)2.339Mcwi null Rattus norvegicus
Strain F344-Ppp2r2bTn(sb-T2/Bart3)2.239Mcwi null Rattus norvegicus
Strain F344-Prr5lTn(sb-T2/Bart3)2.228Mcwi null Rattus norvegicus
Strain F344-PtpraTn(sb-T2/Bart3)2.261Mcwi null Rattus norvegicus
Strain F344-PtpreTn(sb-T2/Bart3)236Mcwi null Rattus norvegicus
Strain F344-Rap1gds1Tn(sb-T2/Bart3)2.251Mcwi null Rattus norvegicus
Strain F344-Rapgef4Tn(sb-T2/Bart3)2.314Mcwi null Rattus norvegicus
Strain F344-RGD1563503Tn(sb-T2/Bart3)2.313Mcwi null Rattus norvegicus
Strain F344-RGD1564304Tn(sb-T2/Bart3)2.201Mcwi null Rattus norvegicus
Strain F344-RGD1565323Tn(sb-T2/Bart3)2.312Mcwi null Rattus norvegicus
Strain F344-Robo1Tn(sb-T2/Bart3)2.327Mcwi null Rattus norvegicus
Strain F344-RorbTn(sb-T2/Bart3)2.304Mcwi null Rattus norvegicus
Strain F344-Rph3aTn(sb-T2/Bart3)2.104Mcwi null Rattus norvegicus
Strain F344-Rprd1aTn(sb-T2/Bart3)2.247Mcwi null Rattus norvegicus
Strain F344-Rtn4Tn(sb-T2/Bart3)2.316Mcwi null Rattus norvegicus
Strain F344-Sf4Tn(sb-T2/Bart3)2.264Mcwi null Rattus norvegicus
Strain F344-Slc16a12Tn(sb-T2/Bart3)2.298Mcwi null Rattus norvegicus
Strain F344-Slc24a3Tn(sb-T2/Bart3)2.178Mcwi null Rattus norvegicus
Strain F344-Slc24a3Tn(sb-T2/Bart3)2.188Mcwi null Rattus norvegicus
Strain F344-Slc24a4Tn(sb-T2/Bart3)2.145Mcwi null Rattus norvegicus
Strain F344-Slc7a11Tn(sb-T2/Bart3)2.266Mcwi null Rattus norvegicus
Strain F344-SnphTn(sb-T2/Bart3)2.214Mcwi null Rattus norvegicus
Strain F344-Snx25Tn(sb-T2/Bart3)2.270Mcwi null Rattus norvegicus
Strain F344-Spata13Tn(sb-T2/Bart3)2.267Mcwi null Rattus norvegicus
Strain F344-Spetex-2HTn(sb-T2/Bart3)2.136Mcwi null Rattus norvegicus
Strain F344-Spta1Tn(sb-T2/Bart3)2.315Mcwi null Rattus norvegicus
Strain F344-Sptbn4Tn(sb-T2/Bart3)2.179Mcwi null Rattus norvegicus
Strain F344-Sptlc3Tn(sb-T2/Bart3)2.147Mcwi null Rattus norvegicus
Strain F344-Stxbp5lTn(sb-T2/Bart3)2.202Mcwi null Rattus norvegicus
Strain F344-Syndig1Tn(sb-T2/Bart3)2.171Mcwi null Rattus norvegicus
Strain F344-Syne1Tn(sb-T2/Bart3)2.68Mcwi null Rattus norvegicus
Strain F344-Tasp1Tn(sb-T2/Bart3)2.219Mcwi null Rattus norvegicus
Strain F344-Tmco1Tn(sb-T2/Bart3)2.135Mcwi null Rattus norvegicus
Strain F344-Tmem22Tn(sb-T2/Bart3)2.332Mcwi null Rattus norvegicus
Strain F344-Tmtc2Tn(sb-T2/Bart3)2.276Mcwi null Rattus norvegicus
Strain F344-TrdnTn(sb-T2/Bart3)2.238Mcwi null Rattus norvegicus
Strain F344-Trpc4Tn(sb-T2/Bart3)2.192Mcwi null Rattus norvegicus
Strain F344-Ubqln4Tn(sb-T2/Bart3)2.230Mcwi null Rattus norvegicus
Strain F344-AW915325Tn(sb-T2/Bart3)2.319Mcwi null Rattus norvegicus
Strain F344-Tg(PGK2-sb11)Ceb Sleeping beauty transposase transgenic Rattus norvegicus
Strain F344-TgTn(T2/Bart3)1Ceb null Rattus norvegicus
Strain F344-TgTn(T2/Bart3)2Ceb transposon sleeping beauty Rattus norvegicus
Gene Fam19a2Tn(sb-T2/Bart3)2.184Mcwi similar to TAFA2 protein; transposon insertion 2.184, Medical College of Wisconsin Rattus norvegicus
Gene Fam227aTn(sb-T2/Bart3)2.333Mcwi family with sequence similarity 227, member A; transposon insertion 2.333, Medical College of Wisconsin Rattus norvegicus
Gene FaslgTn(sb-T2/Bart3)2.325Mcwi Fas ligand (TNF superfamily, member 6); transposon insertion 2.324, Medical College of Wisconsin Rattus norvegicus
Gene FM117003Tn(sb-T2/Bart3)2.321Mcwi EST FM117003; transposon insertion 2.321, Medical College of Wisconsin Rattus norvegicus
Gene Galntl6Tn(sb-T2/Bart3)2.311Mcwi UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-like 6; transposon insertion 2.309, Medical College of Wisconsin Rattus norvegicus
Gene Glis1Tn(sb-T2/Bart3)2.149Mcwi GLIS family zinc finger 1 ; transposon insertion 2.149, Medical College of Wisconsin Rattus norvegicus
Gene Gng12Tn(sb-T2/Bart3)2.320Mcwi guanine nucleotide binding protein (G protein), gamma 12; transposon insertion 2.320, Medical College of Wisconsin Rattus norvegicus
Gene Gramd1bTn(sb-T2/Bart3)2.287Mcwi GRAM domain containing 1B; transposon insertion 2.287, Medical College of Wisconsin Rattus norvegicus
Gene Grk1Tn(sb-T2/Bart3)2.234Mcwi G protein-coupled receptor kinase 1; transposon insertion 2.234, Medical College of Wisconsin Rattus norvegicus
Gene Immp1lTn(sb-T2/Bart3)2.246Mcwi IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae); transposon insertion 2.246, Medical College of Wisconsin Rattus norvegicus
Gene Inpp4bTn(sb-T2/Bart3)2.143Mcwi inositol polyphosphate-4-phosphatase, type II; transposon insertion 2.143, Medical College of Wisconsin Rattus norvegicus
Gene Inpp4bTn(sb-T2/Bart3)2.232Mcwi inositol polyphosphate-4-phosphatase, type II; transposon insertion 2.232, Medical College of Wisconsin Rattus norvegicus
Gene IntuTn(sb-T2/Bart3)2.324Mcwi inturned planar cell polarity effector homolog (Drosophila); transposon insertion 2.324, Medical College of Wisconsin Rattus norvegicus
Gene Kcnab1Tn(sb-T2/Bart3)2.300Mcwi potassium voltage-gated channel, shaker-related subfamily, beta member 1; transposon insertion 2.300, Medical College of Wisconsin Rattus norvegicus
Gene Kcnh7Tn(sb-T2/Bart3)2.295Mcwi potassium voltage-gated channel, subfamily H (eag-related), member 7; transposon insertion 2.295, Medical College of Wisconsin Rattus norvegicus
Gene Kcnip4Tn(sb-T2/Bart3)2.225Mcwi Kv channel interacting protein 4; transposon insertion 2.225, Medical College of Wisconsin Rattus norvegicus
Gene Kif16bTn(sb-T2/Bart3)2.200Mcwi kinesin family member 16B; transposon insertion 2.200, Medical College of Wisconsin Rattus norvegicus
Gene Klhl13Tn(sb-T2/Bart3)2.176Mcwi kelch-like 13 (Drosophila); transposon insertion 2.176, Medical College of Wisconsin Rattus norvegicus
Gene Klra1Tn(sb-T2/Bart3)2.279Mcwi killer cell lectin-like receptor, subfamily A, member 1; transposon insertion 2.279, Medical College of Wisconsin Rattus norvegicus
Gene Lama2Tn(sb-T2/Bart3)2.2013Mcwi laminin, alpha 2; transposon insertion 2.213, Medical College of Wisconsin Rattus norvegicus
Gene LargeTn(sb-T2/Bart3)2.336Mcwi like-glycosyltransferase; transposon insertion 2.336, Medical College of Wisconsin Rattus norvegicus
Gene Lims1Tn(sb-T2/Bart3)2.169Mcwi LIM zinc finger domain containing 1; transposon insertion 2.169, Medical College of Wisconsin Rattus norvegicus
Gene LmlnTn(sb-T2/Bart3)2.322Mcwi leishmanolysin-like (metallopeptidase M8 family); transposon insertion 2.322, Medical College of Wisconsin Rattus norvegicus
Gene LOC290071Tn(sb-T2/Bart3)2.170Mcwi similar to RIKEN cDNA A430107P09 gene; transposon insertion 2.170, Medical College of Wisconsin Rattus norvegicus
Gene LOC681893Tn(sb-T2/Bart3)2.159Mcwi similar to SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Liver regeneration-related protein LRRGR00002); transposon insertion 2.159, Medical College of Wisconsin Rattus norvegicus
Gene LOC681893Tn(sb-T2/Bart3)2.161Mcwi similar to SET protein (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I) (Liver regeneration-related protein LRRGR00002); transposon insertion 2.161, Medical College of Wisconsin Rattus norvegicus
Gene Lrrc4cTn(sb-T2/Bart3)2.224Mcwi leucine rich repeat containing 4C; transposon insertion 2.224, Medical College of Wisconsin Rattus norvegicus
Gene Lrrc4cTn(sb-T2/Bart3)2.254Mcwi leucine rich repeat containing 4C; transposon insertion 2.254, Medical College of Wisconsin Rattus norvegicus
Gene Lrrc7Tn(sb-T2/Bart3)2.253Mcwi leucine rich repeat containing 7; transposon insertion 2.253, Medical College of Wisconsin Rattus norvegicus
Gene LzicTn(sb-T2/Bart3)2.309Mcwi leucine zipper and CTNNBIP1 domain containing; transposon insertion 2.309, Medical College of Wisconsin Rattus norvegicus
Gene Map2k5Tn(sb-T2/Bart3)2.150Mcwi mitogen activated protein kinase kinase 5; transposon insertion 2.150, Medical College of Wisconsin Rattus norvegicus
Gene Mgat4cTn(sb-T2/Bart3)2.244Mcwi mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative); transposon insertion 2.244, Medical College of Wisconsin Rattus norvegicus
Gene Mmel1Tn(sb-T2/Bart3)2.255Mcwi membrane metallo-endopeptidase-like 1; transposon insertion 2.255, Medical College of Wisconsin Rattus norvegicus
Gene Mov10Tn(sb-T2/Bart3)2.281Mcwi Moloney leukemia virus 10; transposon insertion 2.281, Medical College of Wisconsin Rattus norvegicus
Gene Myo1dTn(sb-T2/Bart3)2.334Mcwi myosin ID; transposon insertion 2.334, Medical College of Wisconsin Rattus norvegicus
Gene Myo9aTn(sb-T2/Bart3)2.186Mcwi myosin IXA; transposon insertion 2.186, Medical College of Wisconsin Rattus norvegicus
Gene NapbTn(sb-T2/Bart3)2.162Mcwi similar to N-ethylmaleimide sensitive fusion protein attachment protein beta; transposon insertion 2.162, Medical College of Wisconsin Rattus norvegicus
Gene Nectin1Tn(sb-T2/Bart3)2.284Mcwi nectin cell adhesion molecule 1; transposon insertion 2.284, Medical College of Wisconsin Rattus norvegicus
Gene Nell1Tn(sb-T2/Bart3)2.195Mcwi NEL-like 1 (chicken); transposon insertion 2.195, Medical College of Wisconsin Rattus norvegicus
Gene Nrg1Tn(sb-T2/Bart3)2.183Mcwi neuregulin 1; transposon insertion 2.183, Medical College of Wisconsin Rattus norvegicus
Gene Nrxn2Tn(sb-T2/Bart3)2.250Mcwi neurexin 2; transposon insertion 2.250, Medical College of Wisconsin Rattus norvegicus
Gene Nsun4Tn(sb-T2/Bart3)2.286Mcwi NOL1/NOP2/Sun domain family, member 4; transposon insertion 2.286, Medical College of Wisconsin Rattus norvegicus
Gene NtmTn(sb-T2/Bart3)2.130Mcwi neurotrimin; transposon insertion 2.130, Medical College of Wisconsin Rattus norvegicus
Gene Orc3Tn(sb-T2/Bart3)2.275Mcwi origin recognition complex, subunit 3-like (yeast); transposon insertion 2.275, Medical College of Wisconsin Rattus norvegicus
Gene P3h3Tn(sb-T2/Bart3)2.310Mcwi prolyl 3-hydroxylase 3; transposon insertion 2.310, Medical College of Wisconsin Rattus norvegicus
Gene PalldTn(sb-T2/Bart3)2.341Mcwi palladin, cytoskeletal associated protein; transposon insertion 2.341, Medical College of Wisconsin Rattus norvegicus
Gene PatjTn(sb-T2/Bart3)2.343Mcwi PATJ, crumbs cell polarity complex component; transposon insertion 2.343, Medical College of Wisconsin Rattus norvegicus
Gene Pde4dTn(sb-T2/Bart3)2.285Mcwi phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); transposon insertion 2.285, Medical College of Wisconsin Rattus norvegicus
Gene Pde5aTn(sb-T2/Bart3)2.144Mcwi phosphodiesterase 5A, cGMP-specific; transposon insertion 2.144, Medical College of Wisconsin Rattus norvegicus
Gene Pebp4Tn(sb-T2/Bart3)2.299Mcwi phosphatidylethanolamine binding protein 4; transposon insertion 2.299, Medical College of Wisconsin Rattus norvegicus
Gene Plcb3Tn(sb-T2/Bart3)2.69Mcwi phospholipase C, beta 3; transposon insertion 2.69, Medical College of Wisconsin Rattus norvegicus
Gene Plce1Tn(sb-T2/Bart3)2.146Mcwi phospholipase C, epsilon 1; transposon insertion 2.146, Medical College of Wisconsin Rattus norvegicus
Gene Pld5Tn(sb-T2/Bart3)2.340Mcwi phospholipase D family, member 5; transposon insertion 2.340, Medical College of Wisconsin Rattus norvegicus
Gene Ppapdc1aTn(sb-T2/Bart3)2.207Mcwi phosphatidic acid phosphatase type 2 domain containing 1A; transposon insertion 2.207, Medical College of Wisconsin Rattus norvegicus
Gene Ppfia2Tn(sb-T2/Bart3)2.339Mcwi protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2; transposon insertion 2.339, Medical College of Wisconsin Rattus norvegicus
Gene Ppp2r2bTn(sb-T2/Bart3)2.239Mcwi protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform; transposon insertion 2.239, Medical College of Wisconsin Rattus norvegicus
Gene Prr5lTn(sb-T2/Bart3)2.228Mcwi proline rich 5 like; transposon insertion 2.228, Medical College of Wisconsin Rattus norvegicus
Gene PtpraTn(sb-T2/Bart3)2.261Mcwi protein tyrosine phosphatase, receptor type, A; transposon insertion 2.261, Medical College of Wisconsin Rattus norvegicus
Gene PtpreTn(sb-T2/Bart3)236Mcwi protein tyrosine phosphatase, receptor type, E; transposon insertion 2.236, Medical College of Wisconsin Rattus norvegicus
Gene Rap1gds1Tn(sb-T2/Bart3)2.251Mcwi RAP1, GTP-GDP dissociation stimulator 1; transposon insertion 2.251, Medical College of Wisconsin Rattus norvegicus
Gene Rapgef4Tn(sb-T2/Bart3)2.314Mcwi Rap guanine nucleotide exchange factor (GEF) 4; transposon insertion 2.314, Medical College of Wisconsin Rattus norvegicus
Gene RGD1563503Tn(sb-T2/Bart3)2.313Mcwi similar to ribosomal protein L6; transposon insertion 2.313, Medical College of Wisconsin Rattus norvegicus
Gene RGD1564304Tn(sb-T2/Bart3)2.201Mcwi RGD1564304; transposon insertion 2.201, Medical College of Wisconsin Rattus norvegicus
Gene RGD1565323Tn(sb-T2/Bart3)2.312Mcwi similar to OTTMUSP00000000621; transposon insertion 2.312, Medical College of Wisconsin Rattus norvegicus
Gene Robo1Tn(sb-T2/Bart3)2.327Mcwi roundabout homolog 1 (Drosophila); transposon insertion 2.327, Medical College of Wisconsin Rattus norvegicus
Gene RorbTn(sb-T2/Bart3)2.304Mcwi RAR-related orphan receptor B; transposon insertion 2.304, Medical College of Wisconsin Rattus norvegicus
Gene Rph3aTn(sb-T2/Bart3)2.104Mcwi rabphilin 3A; transposon insertion 2.104, Medical College of Wisconsin Rattus norvegicus
Gene Rprd1aTn(sb-T2/Bart3)2.247Mcwi cyclin-dependent kinase 2B-inhibitor-related protein; transposon insertion 2.247, Medical College of Wisconsin Rattus norvegicus
Gene Rtn4Tn(sb-T2/Bart3)2.316Mcwi reticulon 4; transposon insertion 2.316, Medical College of Wisconsin Rattus norvegicus
Gene Sf4Tn(sb-T2/Bart3)2.264Mcwi splicing factor 4; transposon insertion 2.264, Medical College of Wisconsin Rattus norvegicus
Gene Slc16a12Tn(sb-T2/Bart3)2.298Mcwi solute carrier family 16, member 12 (monocarboxylic acid transporter 12); transposon insertion 2.298, Medical College of Wisconsin Rattus norvegicus
Gene Slc24a3Tn(sb-T2/Bart3)2.178Mcwi solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; transposon insertion 2.178, Medical College of Wisconsin Rattus norvegicus
Gene Slc24a3Tn(sb-T2/Bart3)2.188Mcwi solute carrier family 24 (sodium/potassium/calcium exchanger), member 3; transposon insertion 2.188, Medical College of Wisconsin Rattus norvegicus
Gene Slc24a4Tn(sb-T2/Bart3)2.145Mcwi solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 ; transposon insertion 2.145, Medical College of Wisconsin Rattus norvegicus
Gene Slc7a11Tn(sb-T2/Bart3)2.266Mcwi solute carrier family 7 (cationic amino acid transporter, y+ system), member 11; transposon insertion 2.266, Medical College of Wisconsin Rattus norvegicus
Gene SnphTn(sb-T2/Bart3)2.214Mcwi syntaphilin; transposon insertion 2.214, Medical College of Wisconsin Rattus norvegicus
Gene Snx25Tn(sb-T2/Bart3)2.270Mcwi sorting nexin 25; transposon insertion 2.270, Medical College of Wisconsin Rattus norvegicus
Gene Spata13Tn(sb-T2/Bart3)2.267Mcwi spermatogenesis associated 13; transposon insertion 2.267, Medical College of Wisconsin Rattus norvegicus
Gene Spetex-2HTn(sb-T2/Bart3)2.136Mcwi Spetex-2H protein; transposon insertion 2.136, Medical College of Wisconsin Rattus norvegicus
Gene Spta1Tn(sb-T2/Bart3)2.315Mcwi spectrin, alpha, erythrocytic 1 (elliptocytosis 2); transposon insertion 2.315, Medical College of Wisconsin Rattus norvegicus
Gene Sptbn4Tn(sb-T2/Bart3)2.179Mcwi spectrin beta 4; transposon insertion 2.179, Medical College of Wisconsin Rattus norvegicus
Gene Sptlc3Tn(sb-T2/Bart3)2.147Mcwi similar to RIKEN cDNA C130053K05 gene; similar to dJ718P11.1.1 (novel class II aminotransferase similar to serine palmotyltransferase (isoform 1)) ; transposon insertion 2.147, Medical College of Wisconsin Rattus norvegicus
Gene Stxbp5lTn(sb-T2/Bart3)2.202Mcwi syntaxin binding protein 5-like; transposon insertion 2.202, Medical College of Wisconsin Rattus norvegicus
Gene Syndig1Tn(sb-T2/Bart3)2.171Mcwi synapse differentiation inducing 1; transposon insertion 2.171, Medical College of Wisconsin Rattus norvegicus
Gene Syne1Tn(sb-T2/Bart3)2.68Mcwi spectrin repeat containing, nuclear envelope 1; transposon insertion 2.68, Medical College of Wisconsin Rattus norvegicus
Gene Tasp1Tn(sb-T2/Bart3)2.219Mcwi taspase, threonine aspartase 1; transposon insertion 2.219, Medical College of Wisconsin Rattus norvegicus
Gene Tmco1Tn(sb-T2/Bart3)2.135Mcwi transmembrane and coiled-coil domains 1; transposon insertion 2.135, Medical College of Wisconsin Rattus norvegicus
Gene Tmem22Tn(sb-T2/Bart3)2.332Mcwi transmembrane protein 22; transposon insertion 2.332 Medical College of Wisconsin Rattus norvegicus
Gene Tmtc2Tn(sb-T2/Bart3)2.276Mcwi transmembrane and tetratricopeptide repeat containing 2; transposon insertion 2.276, Medical College of Wisconsin Rattus norvegicus
Gene TrdnTn(sb-T2/Bart3)2.238Mcwi triadin; transposon insertion 2.238, Medical College of Wisconsin Rattus norvegicus
Gene Trpc4Tn(sb-T2/Bart3)2.192Mcwi transient receptor potential cation channel, subfamily C, member 4; transposon insertion 2.192, Medical College of Wisconsin Rattus norvegicus
Gene Ubqln4Tn(sb-T2/Bart3)2.230Mcwi ubiquilin 4; transposon insertion 2.230, Medical College of Wisconsin Rattus norvegicus

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