RGD Reference Report - Immunocytochemical localization of growth hormone-releasing factor in the rat hypothalamus. - Rat Genome Database

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Immunocytochemical localization of growth hormone-releasing factor in the rat hypothalamus.

Authors: Merchenthaler, I  Vigh, S  Schally, AV  Petrusz, P 
Citation: Merchenthaler I, etal., Endocrinology. 1984 Apr;114(4):1082-5.
RGD ID: 2289999
Pubmed: PMID:6423368   (View Abstract at PubMed)
DOI: DOI:10.1210/endo-114-4-1082   (Journal Full-text)

The distribution of GRF-immunoreactive structures in the rat hypothalamus was studied after colchicine treatment with peroxidase-antiperoxidase immunocytochemistry in vibratome sections. The majority of the GRF-immunoreactive cell bodies were found in the arcuate nucleus and the medial perifornical region of the lateral hypothalamus. Scattered cells were seen in the lateral basal hypothalamus, the medial and lateral portions of the ventromedial nucleus, and the dorsomedial and paraventricular nuclei. Fibers from the perifornical cell bodies formed a fan-like projection to the median eminence, where a dense accumulation of GRF-containing processes and terminals was found. GRF terminals were located in the central regions of the median eminence. The localization of GRF-immunoreactive structures in the hypothalamus and median eminence reinforces the view that GRF plays a physiological role in the regulation of pituitary function.

Gene Ontology Annotations    Click to see Annotation Detail View

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
axon terminus  IDA 2289999hypothalamusRGD 
perikaryon  IDA 2289999hypothalamusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Ghrh  (growth hormone releasing hormone)


Additional Information