RGD Reference Report - Neuregulin-1 enhances depolarization-induced GABA release. - Rat Genome Database

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Neuregulin-1 enhances depolarization-induced GABA release.

Authors: Woo, RS  Li, XM  Tao, Y  Carpenter-Hyland, E  Huang, YZ  Weber, J  Neiswender, H  Dong, XP  Wu, J  Gassmann, M  Lai, C  Xiong, WC  Gao, TM  Mei, L 
Citation: Woo RS, etal., Neuron. 2007 May 24;54(4):599-610.
RGD ID: 2289989
Pubmed: PMID:17521572   (View Abstract at PubMed)
DOI: DOI:10.1016/j.neuron.2007.04.009   (Journal Full-text)

Neuregulin-1 (NRG1), a regulator of neural development, has been shown to regulate neurotransmission at excitatory synapses. Although ErbB4, a key NRG1 receptor, is expressed in glutamic acid decarboxylase (GAD)-positive neurons, little is known about its role in GABAergic transmission. We show that ErbB4 is localized at GABAergic terminals of the prefrontal cortex. Our data indicate a role of NRG1, both endogenous and exogenous, in regulation of GABAergic transmission. This effect was blocked by inhibition or mutation of ErbB4, suggesting the involvement of ErbB4. Together, these results indicate that NRG1 regulates GABAergic transmission via presynaptic ErbB4 receptors, identifying a novel function of NRG1. Because both NRG1 and ErbB4 have emerged as susceptibility genes of schizophrenia, these observations may suggest a mechanism for abnormal GABAergic neurotransmission in this disorder.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
positive regulation of synaptic transmission, GABAergic  IMP 2289989 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)


Additional Information