RGD Reference Report - Nuclear and cytoplasmic expression of ErbB-4 in prostate cancer. - Rat Genome Database

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Nuclear and cytoplasmic expression of ErbB-4 in prostate cancer.

Authors: Ben-Yosef, R  Sarid, D  Vexler, A  Lidawi, G  Inbar, M  Marmor, S  Starr, A  Yaal Hahoshen, N 
Citation: Ben-Yosef R, etal., Int J Biol Markers. 2007 Jul-Sep;22(3):181-5.
RGD ID: 2289978
Pubmed: PMID:17922460   (View Abstract at PubMed)

PURPOSE: To evaluate cytoplasmic and nuclear ErbB-4 expression in prostate cancer specimens and its association with outcome. BASIC PROCEDURES: Specimens of 50 prostate cancer patients were investigated for ErbB-4 overexpression using Immunohistochemistry staining. Cytoplasmic and nuclear staining was graded as 0-3 according to its intensity. The prognostic parameters were tumor stage, PSA level, Gleason score, probability of positive lymph nodes (Partin's tables and Roach equation), and 5-year disease free survival (Kattan nomogram). MAIN FINDINGS: Overexpression of ErbB-4 (> or = 1) was detected in 30 (60%) patients and overexpression using cytoplasmic and nuclear staining was > or = 2 in 19 (38%) and 17 (34%) patients, respectively. In only one third of the specimens was there any similarity between the 2 types of staining. Advanced tumor stage, high pretreatment PSA levels and high Gleason scores were evenly distributed among the patients with low (< or = 1) and intermediate/high (> or = 2) ErbB-4 expression. The probability of lymph node involvement and 5-year disease free survival were similar in both types of staining. PRINCIPAL CONCLUSIONS: ErbB-4 was overexpressed (cytoplasmic and nuclear staining) in approximately one third of prostate cancer patients. The rate of similarity between the 2 staining types was only 33%: overexpression was evenly distributed among intermediate/high and low risk prostate cancer patients with both staining methods.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
prostate cancer  IEP 2289978protein:increased expression:prostate glandRGD 
prostate cancer  ISOERBB4 (Homo sapiens)2289978; 2289978protein:increased expression:prostate glandRGD 

Objects Annotated

Genes (Rattus norvegicus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)

Genes (Mus musculus)
Erbb4  (erb-b2 receptor tyrosine kinase 4)

Genes (Homo sapiens)
ERBB4  (erb-b2 receptor tyrosine kinase 4)


Additional Information