RGD Reference Report - HER-2 gene amplification in Paget disease of the nipple and extramammary site: a chromogenic in situ hybridization study. - Rat Genome Database

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HER-2 gene amplification in Paget disease of the nipple and extramammary site: a chromogenic in situ hybridization study.

Authors: Bianco, MK  Vasef, MA 
Citation: Bianco MK and Vasef MA, Diagn Mol Pathol. 2006 Sep;15(3):131-5.
RGD ID: 2289933
Pubmed: PMID:16932067   (View Abstract at PubMed)
DOI: DOI:10.1097/01.pdm.0000213456.30151.5b   (Journal Full-text)

Patients with human epidermal growth factor receptor 2 (HER-2) overexpressing breast carcinomas have a more aggressive clinical behavior and their tumors are often hormone receptor negative. However, the recently introduced anti-HER-2 antibody trastuzumab has been proven to improve the survival and controls the disease in a significant proportion of these patients. Therefore, the analysis of HER-2 in patients with breast cancer has become an important and routine test to select those who may benefit from the gene-based targeted therapy trastuzumab (herceptin). There is good correlation between HER-2/neu protein overexpression and HER-2 gene amplification in breast cancer. However, inconsistent results have been reported in the rate of HER-2/neu protein overexpression in other malignant neoplasms. Furthermore, only rare studies have investigated the correlation between the HER-2/neu protein overexpression and the status of HER-2 gene in these tumors. We investigated the HER-2 gene and protein status in several cases of Paget disease of the nipple and vulva by using a chromogenic in situ hybridization assay and immunohistochemistry. We find that the majority of the Paget disease of the breast demonstrate HER-2 gene amplification, whereas most of the extramammary Paget disease lack HER-2 gene amplification. In addition, our results show a good correlation between HER-2/neu protein overexpression and HER-2 gene amplification in Paget disease of the nipple, but we were unable to confirm this correlation in HER-2/neu protein overexpressing Paget disease of the vulva.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
mammary Paget's disease  IAGP 2289933DNA:amplificationRGD 
mammary Paget's disease  ISOERBB2 (Homo sapiens)2289933; 2289933DNA:amplificationRGD 

Objects Annotated

Genes (Rattus norvegicus)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Genes (Mus musculus)
Erbb2  (erb-b2 receptor tyrosine kinase 2)

Genes (Homo sapiens)
ERBB2  (erb-b2 receptor tyrosine kinase 2)


Additional Information