RGD Reference Report - Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia. - Rat Genome Database

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Traumatic brain injury stimulates hippocampal catechol-O-methyl transferase expression in microglia.

Authors: Redell, JB  Dash, PK 
Citation: Redell JB and Dash PK, Neurosci Lett. 2007 Feb 8;413(1):36-41. Epub 2006 Dec 15.
RGD ID: 2289740
Pubmed: PMID:17240060   (View Abstract at PubMed)
PMCID: PMC1857315   (View Article at PubMed Central)
DOI: DOI:10.1016/j.neulet.2006.11.060   (Journal Full-text)

Outcome following traumatic brain injury (TBI) is in large part determined by the combined action of multiple processes. In order to better understand the response of the central nervous system to injury, we utilized an antibody array to simultaneously screen 507 proteins for altered expression in the injured hippocampus, a structure critical for memory formation. Array analysis indicated 41 candidate proteins have altered expression levels 24h after TBI. Of particular interest was catechol-O-methyl transferase (COMT), an enzyme involved in metabolizing catecholamines released following neuronal activity. Altered catecholamine signaling has been observed after brain injury, and may contribute to the cognitive dysfunctions and behavioral deficits often experienced after TBI. Our data shows that COMT expression in the injured ipsilateral hippocampus was elevated for at least 14 d after controlled cortical impact injury. We found strong co-localization of COMT immunoreactivity with the microglia marker Iba1 near the injury site. Since dopamine transporter expression has been reported to be down-regulated after brain injury, COMT-mediated catecholamine metabolism may play a more prominent role in terminating catecholamine signaling in injured areas.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Brain Injuries  ISOComt (Rattus norvegicus)2289740; 2289740protein:increased expression:hippocampusRGD 
Brain Injuries  IEP 2289740protein:increased expression:hippocampusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Comt  (catechol-O-methyltransferase)

Genes (Mus musculus)
Comt  (catechol-O-methyltransferase)

Genes (Homo sapiens)
COMT  (catechol-O-methyltransferase)


Additional Information