RGD Reference Report - Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas. - Rat Genome Database

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Hormonal regulation of catechol-O-methyl transferase activity in women with uterine leiomyomas.

Authors: Salama, SA  Ho, SL  Wang, HQ  Tenhunen, J  Tilgmann, C  Al-Hendy, A 
Citation: Salama SA, etal., Fertil Steril. 2006 Jul;86(1):259-62. Epub 2006 May 26.
RGD ID: 2289717
Pubmed: PMID:16730007   (View Abstract at PubMed)
DOI: DOI:10.1016/j.fertnstert.2005.12.049   (Journal Full-text)

Catechol-O-methyl transferase (COMT) expression is higher in leiomyomas compared with paired normal myometrium. The expression of COMT in leiomyoma cells is hormonally regulated-estrogen down-regulates, whereas P and dexamethasone up-regulate, COMT expression.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
leiomyoma  IEP 2289717protein:increased expression:myometriumRGD 
leiomyoma  ISOCOMT (Homo sapiens)2289717; 2289717protein:increased expression:myometriumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Comt  (catechol-O-methyltransferase)

Genes (Mus musculus)
Comt  (catechol-O-methyltransferase)

Genes (Homo sapiens)
COMT  (catechol-O-methyltransferase)


Additional Information