RGD Reference Report - Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma. - Rat Genome Database

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Tissue microarray analysis of FAS, Bcl-2, Bcl-x, ER, PgR, Hsp60, p53 and Her2-neu in breast carcinoma.

Authors: Sebastiani, V  Botti, C  Di Tondo, U  Visca, P  Pizzuti, L  Santeusanio, G  Alo, PL 
Citation: Sebastiani V, etal., Anticancer Res. 2006 Jul-Aug;26(4B):2983-7.
RGD ID: 1643480
Pubmed: PMID:16886624   (View Abstract at PubMed)

BACKGROUND: The aim of this study was to detect immunohistochemical markers in breast carcinoma by means of tissue microarray analysis (TMA) and to associate their expressions with clinicopathological features and prognosis. Fatty acid synthase, bcl-2, bcl-x, p53, estrogen and progesterone receptors, heat shock protein 60 and Her2-neu (c-erbB-2) were evaluated in a group of 149 breast carcinoma patients with a 5-year follow-up period. MATERIALS AND METHODS: TMA blocks were made by using duplicate 0.6-mm diameter tissue cores from each paraffin block. RESULTS: Statistical analysis revealed that tumor stage (p=0.003) and node status (p=0.001) were the only two prognostic markers of disease-free survival. Moreover, FAS and bcl-x showed an independent effect on recurrence (p=0.005). The node status was the only marker of overall survival (p=0.05). CONCLUSION: Our data confirmed recent reports associating the stage of disease, FAS and Bcl-x expressions with recurrence and outcome. These data demonstrated that TMA is an effective substitute for conventional histochemical-immunohistochemical techniques.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
breast carcinoma  IEP 1643480 RGD 
breast carcinoma  ISOBCL2L1 (Homo sapiens)1643480; 1643480 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Bcl2l1  (Bcl2-like 1)

Genes (Mus musculus)
Bcl2l1  (BCL2-like 1)

Genes (Homo sapiens)
BCL2L1  (BCL2 like 1)


Additional Information