RGD Reference Report - ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation. - Rat Genome Database

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ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation.

Authors: Degoutin, J  Vigny, M  Gouzi, JY 
Citation: Degoutin J, etal., FEBS Lett. 2007 Feb 20;581(4):727-34. Epub 2007 Jan 25.
RGD ID: 1643181
Pubmed: PMID:17274988   (View Abstract at PubMed)
DOI: DOI:10.1016/j.febslet.2007.01.039   (Journal Full-text)

Activation of the neuronal receptor tyrosine kinase ALK (anaplastic lymphoma kinase) promoted the neuron-like differentiation of PC12 cells through specific activation of the ERK MAP-kinase pathway. However, the nature of primary signaling events initiated is still poorly documented. Here, we established that Shc and FRS2 adaptors were recruited and phosphorylated following antibody-based ALK activation. We further demonstrated that Shc was recruited to the consensus phosphotyrosine site NPTpY(1507) and FRS2 was likely recruited to a novel non-orthodox phosphotyrosine site within ALK. Finally, we characterized a functional role for Shc and likely FRS2 in ALK-dependant MAP-kinase activation and neuronal differentiation of PC12 cells. These findings hence open attractive perspectives concerning specific characteristics of ALK in the control of the mechanisms driving neuronal differentiation.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
neuron differentiation  IMP 1643181 RGD 

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
protein-containing complex binding  IPIALK (Homo sapiens)1643181 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Shc1  (SHC adaptor protein 1)


Additional Information