RGD Reference Report - LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses. - Rat Genome Database

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LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses.

Authors: Dunah, AW  Hueske, E  Wyszynski, M  Hoogenraad, CC  Jaworski, J  Pak, DT  Simonetta, A  Liu, G  Sheng, M 
Citation: Dunah AW, etal., Nat Neurosci. 2005 Apr;8(4):458-67. Epub 2005 Mar 6.
RGD ID: 1642736
Pubmed: PMID:15750591   (View Abstract at PubMed)
DOI: DOI:10.1038/nn1416   (Journal Full-text)

Leukocyte common antigen-related (LAR) family receptor protein tyrosine phosphatases (LAR-RPTP) bind to liprin-alpha (SYD2) and are implicated in axon guidance. We report that LAR-RPTP is concentrated in mature synapses in cultured rat hippocampal neurons, and is important for the development and maintenance of excitatory synapses in hippocampal neurons. RNA interference (RNAi) knockdown of LAR or dominant-negative disruption of LAR function results in loss of excitatory synapses and dendritic spines, reduction of surface AMPA receptors, impairment of dendritic targeting of the cadherin-beta-catenin complex, and reduction in the amplitude and frequency of miniature excitatory postsynaptic currents (mEPSCs). Cadherin, beta-catenin and GluR2/3 are tyrosine phosphoproteins that coimmunoprecipitate with liprin-alpha and GRIP from rat brain extracts. We propose that the cadherin-beta-catenin complex is cotransported with AMPA receptors to synapses and dendritic spines by a mechanism that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

Cellular Component
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
excitatory synapse  IDA 1642736 RGD 
postsynaptic density membrane is_active_inIDA 1642736PMID:15750591SynGO 
postsynaptic density membrane is_active_inIEP 1642736PMID:15750591SynGO 

Objects Annotated

Genes (Rattus norvegicus)
Ptprf  (protein tyrosine phosphatase, receptor type, F)


Additional Information